Imeglymina wzmacnia stymulowane glukozą uwalnianie insuliny z wysp cukrzycowych poprzez odrębny mechanizm działania

Dysfunkcja komórek β wysepek trzustkowych charakteryzuje się wadliwym wydzielaniem insuliny stymulowanym glukozą (GSIS) i jest dominującym składnikiem patofizjologii cukrzycy. Imeglimin, nowatorski, pierwszy w klasie kandydat na lek drobnocząsteczkowy tetrahydrotriazyna, poprawia glikemię i GSIS w modelach przedklinicznych i badaniach klinicznych u pacjentów z cukrzycą typu 2; jednak mechanizm przywracania funkcji komórek beta jest nieznany. Tutaj pokazujemy, że imeglamina ostro i bezpośrednio wzmacnia GSIS w wysepkach izolowanych od gryzoni z cukrzycą typu 2 poprzez sposób działania, który różni się od innych znanych podejść terapeutycznych.

Podstawowy mechanizm obejmuje zwiększenie puli komórkowego dinukleotydu nikotynamidoadeninowego (NAD +) – potencjalnie poprzez szlak ratunkowy i indukcję fosforybozylotransferazy nikotynamidowej (NAMPT) wraz ze wzrostem poziomów ATP indukowanych przez glukozę.

Ponadto dodatkowe wyniki sugerują, że konwersja NAD + do drugiego przekaźnika, cyklicznej rybozy ADP (cADPR), poprzez cyklazę rybozylową / hydrolazę ADP / cADPR (CD38) jest wymagana do działania imegliminy na wysepkach, co stanowi potencjalny związek między zwiększonym NAD + i zwiększoną glukozą wywołała mobilizację Ca2 +, która z kolei, jak wiadomo, napędza egzocytozę granulek insuliny. Podsumowując, odkrycia te wskazują na nowy sposób działania imegliminy, który wyjaśnia jej zdolność do skutecznego przywracania funkcji komórek beta i zapewnia nowe podejście do leczenia pacjentów cierpiących na cukrzycę typu 2.

Ubezpieczenie i korzystanie z opieki zdrowotnej wśród dzieci chorych na cukrzycę

Ubezpieczenie zdrowotne może być związane z leczeniem cukrzycy u dzieci (DM). Nie wiadomo jednak, w jaki sposób ciągłość ochrony ubezpieczeniowej wiąże się z wynikami korzystania z opieki zdrowotnej w przypadku cukrzycy u dzieci. Skorzystaliśmy z ogólnokrajowego badania zdrowia dzieci 2016-2019, aby zbadać, jak przerwanie ubezpieczenia zdrowotnego może wpłynąć na korzystanie z opieki zdrowotnej wśród dzieci z DM. Analizą objęto dzieci w wieku 0-17 lat z DM. Wyniki obejmowały wizyty na oddziałach ratunkowych, wizyty u specjalistów i niezaspokojone potrzeby w zakresie opieki zdrowotnej w ciągu ostatnich 12 miesięcy.

Ochrona ubezpieczeniowa została sklasyfikowana jako ciągła prywatna, ciągła publiczna lub nieciągła (w tym przerwy w ochronie i całoroczny brak ochrony). Na podstawie próby 548 dzieci 56% miało ciągłe ubezpieczenie prywatne, w porównaniu do 32% z ciągłym ubezpieczeniem publicznym i 12% z nieciągłym ubezpieczeniem. Trzydzieści pięć procent dzieci odwiedziło oddział ratunkowy w ciągu ostatnich 12 miesięcy, a tylko 47% odwiedziło jakiegokolwiek specjalistę w ciągu ostatnich 12 miesięcy, w tym między innymi endokrynologa dziecięcego.

Szacuje się, że 19% dzieci miało niezaspokojone potrzeby zdrowotne w ciągu ostatnich 12 miesięcy. W analizie wieloczynnikowej dzieci z lukami w pokryciu były istotnie rzadziej niż dzieci z ciągłym prywatnym zasięgiem wizyt u specjalisty w ciągu ostatnich 12 miesięcy (skorygowany iloraz szans: 0,27; 95% CI: 0,08; 0,88; p = 0,030). Niniejsze badanie wskazuje na potrzebę ustanowienia i prowadzenia specjalistycznej opieki kontrolnej dla dzieci z DM, zwłaszcza ze środowisk defaworyzowanych społeczno-ekonomicznie. Ten artykuł jest chroniony prawem autorskim. Wszelkie prawa zastrzeżone.

Wyłaniające się role inhibitorów dipeptydylopeptydazy-4 w opóźnianiu progresji cukrzycy typu 1

Cukrzyca typu 1 (T1DM) jest wynikiem zniszczenia funkcjonalnych komórek β trzustki za pośrednictwem komórek odpornościowych. W okresie przedobjawowym T1DM charakteryzuje się obecnością dwóch lub więcej autoprzeciwciał przeciwko komórkom wysp trzustkowych u pacjentów bez dekompensacji glikemii. Strategie terapeutyczne, które mogą modyfikować proces autoimmunologiczny, mogą spowolnić postęp T1DM.

Peptydaza dipeptydylowa-4 (DPP-4) lub CD26, wielofunkcyjna proteaza serynowa o podwójnej funkcji (proteaza regulatorowa i białko wiążące), może modulować stan zapalny i niszczenie komórek beta za pośrednictwem komórek odpornościowych. CD26 bierze udział w kostymulacji limfocytów T, migracji, rozwoju pamięci, dojrzewaniu grasicy i wzorcach emigracji. DPP-4 degraduje hormony peptydowe GLP-1 i GIP. Oprócz regulacji metabolizmu glukozy DPP-4 wywiera działanie przeciwapoptotyczne, regeneracyjne i proliferacyjne, promując ekspansję masy komórek β.

Sygnalizacja receptora GLP-1 może regulować proliferację mysich limfocytów i utrzymanie obwodowych regulatorowych komórek T. U pacjentów z T1DM aktywność DPP-4 w surowicy jest podwyższona. Kilka badań sugeruje, że podwyższona aktywność DPP-4 jest skorelowana z patofizjologią T1DM. DPP-4, który jest preferencyjnie wyrażany na powierzchni Th1, może promować polaryzację odporności Th1, która jest warunkiem wstępnym rozwoju T1DM.

Hamowanie CD26 może hamować proliferację limfocytów T i produkcję cytokin Th1 oraz stymulować wydzielanie czynnika wzrostu guza beta-1 (TGF-β1), który odgrywa ważną rolę w regulacji autoimmunizacji w T1DM. Badania na ludziach lub modelach zwierzęcych T1DM sugerują, że inhibitory DPP-4 mogą poprawiać funkcję komórek beta i osłabiać autoimmunizację, a także zmniejszać zależność od insuliny. W niniejszym przeglądzie podsumowano pojawiające się role inhibitorów DPP-4 w potencjalnym opóźnianiu progresji T1DM.

Korelacje kwasu sialowego z hemoglobiną glikowaną A1c i glikemią u kobiet po menopauzie z cukrzycą typu 2

U kobiet w okresie pomenopauzalnym związane z wiekiem zmiany stanu hormonalnego wiążą się z większym ryzykiem cukrzycy typu 2 i jej powikłań. Uszkodzenie tkanki spowodowane powikłaniami naczyniowymi spowodowanymi cukrzycą może wywołać uwalnianie kwasu sialowego (SA) do ogólnego krążenia, prowadząc do zwiększenia jego stężenia.

Niniejsze badanie jest przekrojowym, jednoośrodkowym badaniem 77 kobiet w okresie pomenopauzalnym. Osoby wybrane do badania podzielono na dwie grupy: i) grupę kontrolną, w skład której wchodziły kobiety po menopauzie bez cukrzycy typu 2 (n = 27); oraz ii) grupę kobiet po menopauzie z rozpoznaniem cukrzycy typu 2 (n = 50).

Rat Clarin-1 (CLRN1) ELISA Kit
MBS285713-48StripWells	MyBiosource	48-Strip-Wells	EUR 445

Rat Clarin-1 (CLRN1) ELISA Kit
MBS285713-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3290

Rat Clarin-1 (CLRN1) ELISA Kit
MBS285713-96StripWells	MyBiosource	96-Strip-Wells	EUR 730

Rat Clarin-1 (CLRN1) ELISA Kit
MBS7225257-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Rat Clarin-1 (CLRN1) ELISA Kit
MBS7225257-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Rat Clarin-1 (CLRN1) ELISA Kit
MBS7225257-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Rat Clarin-1 (CLRN1) ELISA Kit
MBS7225257-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Pig Clarin 1(CLRN1) ELISA kit
E07C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Clarin 1(CLRN1) ELISA kit
E07C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Clarin 1(CLRN1) ELISA kit
E07C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Clarin 1(CLRN1) ELISA kit
E08C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Clarin 1(CLRN1) ELISA kit
E08C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Clarin 1(CLRN1) ELISA kit
E08C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Clarin 1(CLRN1) ELISA kit
E01A46965	BlueGene	96T	EUR 700
Description: ELISA

Goat Clarin 1(CLRN1) ELISA kit
E06C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Clarin 1(CLRN1) ELISA kit
E06C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Clarin 1(CLRN1) ELISA kit
E06C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Goat Clarin 1(CLRN1) ELISA kit
E06C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Clarin 1(CLRN1) ELISA kit
E06C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Human Clarin 1 (CLRN1)ELISA Kit
201-12-2899	Shanghai Sunred Biological Technology	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Clarin 1(CLRN1) ELISA kit
E01A20794	BlueGene	96T	EUR 700
Description: ELISA

Human Clarin 1(CLRN1) ELISA kit
E01A3292	BlueGene	96T	EUR 700
Description: ELISA

Mouse Clarin 1(CLRN1) ELISA kit
E03C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Clarin 1(CLRN1) ELISA kit
E03C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Clarin 1(CLRN1) ELISA kit
E03C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Mouse Clarin 1(CLRN1) ELISA kit
E03C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Clarin 1(CLRN1) ELISA kit
E03C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Sheep Clarin 1(CLRN1) ELISA kit
E01A99259	BlueGene	96T	EUR 700
Description: ELISA

Human Clarin 1(CLRN1) ELISA kit
E01C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Clarin 1(CLRN1) ELISA kit
E01C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Clarin 1(CLRN1) ELISA kit
E01C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Human Clarin 1(CLRN1) ELISA kit
E01C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Clarin 1(CLRN1) ELISA kit
E01C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Mouse Clarin- 1, Clrn1 ELISA KIT
ELI-50519m	Lifescience Market	96 Tests	EUR 1038

Human Clarin 1,CLRN1 ELISA KIT
E2898Hu-1096T	Jiaxing Korain Biotech Ltd (BT Labs)	10*96T	EUR 4122

Human Clarin 1,CLRN1 ELISA KIT
E2898Hu-48wells	Jiaxing Korain Biotech Ltd (BT Labs)	48 wells	EUR 300

Human Clarin 1,CLRN1 ELISA KIT
E2898Hu-596T	Jiaxing Korain Biotech Ltd (BT Labs)	5*96T	EUR 2061

Human Clarin 1,CLRN1 ELISA KIT
E2898Hu-96wells	Jiaxing Korain Biotech Ltd (BT Labs)	96 wells	EUR 458

Sheep Clarin 1(CLRN1) ELISA kit
E14C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Sheep Clarin 1(CLRN1) ELISA kit
E14C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Human Clarin 1,CLRN1 ELISA KIT
JOT-EK2898Hu	Jotbody	96 wells	Ask for price
Description: Human

Human Clarin- 1, CLRN1 ELISA KIT
ELI-25616h	Lifescience Market	96 Tests	EUR 988.8

Human Clarin 1 (CLRN1) ELISA Kit
MBS164441-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3460

Human Clarin 1 (CLRN1) ELISA Kit
MBS164441-48StripWells	MyBiosource	48-Strip-Wells	EUR 285

Human Clarin 1 (CLRN1) ELISA Kit
MBS164441-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 1750

Human Clarin 1 (CLRN1) ELISA Kit
MBS164441-96StripWells	MyBiosource	96-Strip-Wells	EUR 425

Human Clarin 1 (CLRN1) ELISA Kit
MBS7231950-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Human Clarin 1 (CLRN1) ELISA Kit
MBS7231950-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Human Clarin 1 (CLRN1) ELISA Kit
MBS7231950-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Human Clarin 1 (CLRN1) ELISA Kit
MBS7231950-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Human Clarin 1 (CLRN1) ELISA Kit
MBS9303814-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Clarin 1 (CLRN1) ELISA Kit
MBS9303814-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Clarin 1 (CLRN1) ELISA Kit
MBS9303814-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Clarin 1 (CLRN1) ELISA Kit
MBS9303814-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Human Clarin 1 (CLRN1)ELISA Kit
YLA3497HU-48T	Shanghai YL Biotech	48T	Ask for price

Human Clarin 1 (CLRN1)ELISA Kit
YLA3497HU-96T	Shanghai YL Biotech	96T	Ask for price

Canine Clarin 1(CLRN1) ELISA kit
E01A64397	BlueGene	96T	EUR 700
Description: ELISA

Monkey Clarin 1(CLRN1) ELISA kit
E01A73111	BlueGene	96T	EUR 700
Description: ELISA

Rabbit Clarin 1(CLRN1) ELISA kit
E01A29532	BlueGene	96T	EUR 700
Description: ELISA

Bovine Clarin 1(CLRN1) ELISA kit
E01A81830	BlueGene	96T	EUR 700
Description: ELISA

Rabbit Clarin 1(CLRN1) ELISA kit
E04C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Clarin 1(CLRN1) ELISA kit
E04C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Clarin 1(CLRN1) ELISA kit
E04C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Rabbit Clarin 1(CLRN1) ELISA kit
E04C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Clarin 1(CLRN1) ELISA kit
E04C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Canine Clarin 1(CLRN1) ELISA kit
E08C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Canine Clarin 1(CLRN1) ELISA kit
E08C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Monkey Clarin 1(CLRN1) ELISA kit
E09C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Clarin 1(CLRN1) ELISA kit
E09C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Clarin 1(CLRN1) ELISA kit
E09C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Monkey Clarin 1(CLRN1) ELISA kit
E09C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Clarin 1(CLRN1) ELISA kit
E09C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Bovine Clarin 1(CLRN1) ELISA kit
E11C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Bovine Clarin 1(CLRN1) ELISA kit
E11C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Goat Clarin-1 (CLRN1) ELISA Kit
MBS7235421-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Goat Clarin-1 (CLRN1) ELISA Kit
MBS7235421-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Goat Clarin-1 (CLRN1) ELISA Kit
MBS7235421-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Goat Clarin-1 (CLRN1) ELISA Kit
MBS7235421-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Porcine Clarin 1(CLRN1) ELISA kit
E01A55682	BlueGene	96T	EUR 700
Description: ELISA

Porcine Clarin 1(CLRN1) ELISA kit
E07C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Porcine Clarin 1(CLRN1) ELISA kit
E07C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Chicken Clarin 1(CLRN1) ELISA kit
E01A90553	BlueGene	96T	EUR 700
Description: ELISA

Chicken Clarin 1(CLRN1) ELISA kit
E12C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Chicken Clarin 1(CLRN1) ELISA kit
E12C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Human Clarin-1 (CLRN1) ELISA Kit
abx507384-96tests	Abbexa	96 tests	EUR 687.5

Mouse Clarin-1 (CLRN1) ELISA Kit
abx507385-96tests	Abbexa	96 tests	EUR 687.5

Mouse Clarin-1 (CLRN1) ELISA Kit
MBS7221958-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Mouse Clarin-1 (CLRN1) ELISA Kit
MBS7221958-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Mouse Clarin-1 (CLRN1) ELISA Kit
MBS7221958-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Mouse Clarin-1 (CLRN1) ELISA Kit
MBS7221958-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Sheep Clarin-1 (CLRN1) ELISA Kit
MBS7238668-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Sheep Clarin-1 (CLRN1) ELISA Kit
MBS7238668-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Sheep Clarin-1 (CLRN1) ELISA Kit
MBS7238668-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Sheep Clarin-1 (CLRN1) ELISA Kit
MBS7238668-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Canine Clarin-1 (CLRN1) ELISA Kit
MBS7204641-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Canine Clarin-1 (CLRN1) ELISA Kit
MBS7204641-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Canine Clarin-1 (CLRN1) ELISA Kit
MBS7204641-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Canine Clarin-1 (CLRN1) ELISA Kit
MBS7204641-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Monkey Clarin-1 (CLRN1) ELISA Kit
MBS7247455-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Monkey Clarin-1 (CLRN1) ELISA Kit
MBS7247455-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Monkey Clarin-1 (CLRN1) ELISA Kit
MBS7247455-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Monkey Clarin-1 (CLRN1) ELISA Kit
MBS7247455-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Bovine Clarin-1 (CLRN1) ELISA Kit
MBS7244096-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Bovine Clarin-1 (CLRN1) ELISA Kit
MBS7244096-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Bovine Clarin-1 (CLRN1) ELISA Kit
MBS7244096-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Bovine Clarin-1 (CLRN1) ELISA Kit
MBS7244096-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Rabbit Clarin-1 (CLRN1) ELISA Kit
MBS7244180-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Rabbit Clarin-1 (CLRN1) ELISA Kit
MBS7244180-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Rabbit Clarin-1 (CLRN1) ELISA Kit
MBS7244180-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Rabbit Clarin-1 (CLRN1) ELISA Kit
MBS7244180-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Chicken Clarin-1 (CLRN1) ELISA Kit
MBS7200199-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Chicken Clarin-1 (CLRN1) ELISA Kit
MBS7200199-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Chicken Clarin-1 (CLRN1) ELISA Kit
MBS7200199-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Chicken Clarin-1 (CLRN1) ELISA Kit
MBS7200199-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Porcine Clarin-1 (CLRN1) ELISA Kit
MBS7209748-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Porcine Clarin-1 (CLRN1) ELISA Kit
MBS7209748-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Porcine Clarin-1 (CLRN1) ELISA Kit
MBS7209748-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Porcine Clarin-1 (CLRN1) ELISA Kit
MBS7209748-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Guinea Pig Clarin 1(CLRN1) ELISA kit
E01A38247	BlueGene	96T	EUR 700
Description: ELISA

Guinea pig Clarin 1(CLRN1) ELISA kit
E05C1812-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Clarin 1(CLRN1) ELISA kit
E05C1812-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea Pig Clarin 1(CLRN1) ELISA kit
E05C1812-48wellsplate	BlueGene	48 wells plate	EUR 280

Guinea pig Clarin 1(CLRN1) ELISA kit
E05C1812-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Clarin 1(CLRN1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea Pig Clarin 1(CLRN1) ELISA kit
E05C1812-96wellsplate	BlueGene	96 wells plate	EUR 405

Guinea pig Clarin-1 (CLRN1) ELISA Kit
MBS7208659-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Guinea pig Clarin-1 (CLRN1) ELISA Kit
MBS7208659-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Guinea pig Clarin-1 (CLRN1) ELISA Kit
MBS7208659-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Guinea pig Clarin-1 (CLRN1) ELISA Kit
MBS7208659-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Recombinant Rat Clarin-1 (Clrn1)
MBS7011657-002mg	MyBiosource	0.02mg	EUR 1525

Recombinant Rat Clarin-1 (Clrn1)
MBS7011657-01mg	MyBiosource	0.1mg	EUR 2485

Recombinant Rat Clarin-1 (Clrn1)
MBS7011657-5x01mg	MyBiosource	5x0.1mg	EUR 11145

Clrn1 (untagged ORF) - Rat clarin 1 (Clrn1), (10 ug)
RN213201	Origene Technologies GmbH	10 µg	Ask for price

Human Clarin 1, CLRN1 GENLISA ELISA
KBH2898	Krishgen	1 x 96 wells	EUR 286

Recombinant Rat Clarin-1 (Clrn1), partial
MBS7092896-INQUIRE	MyBiosource	INQUIRE	Ask for price

Clrn1 (Myc-DDK-tagged ORF) - Rat clarin 1 (Clrn1), (10 ug)
RR213201	Origene Technologies GmbH	10 µg	Ask for price

Human Clarin 1-CLRN1-ELISA Kit
QY-E05047	Qayee Biotechnology	96T	EUR 460

CLRN1 (untagged)-Human clarin 1 (CLRN1), transcript variant 1
SC306949	Origene Technologies GmbH	10 µg	Ask for price

Recombinant Human Clarin-1 (CLRN1)
MBS7011655-002mg	MyBiosource	0.02mg	EUR 1525

Recombinant Human Clarin-1 (CLRN1)
MBS7011655-01mg	MyBiosource	0.1mg	EUR 2485

Recombinant Human Clarin-1 (CLRN1)
MBS7011655-5x01mg	MyBiosource	5x0.1mg	EUR 11145

Recombinant Mouse Clarin-1 (Clrn1)
MBS7011656-002mg	MyBiosource	0.02mg	EUR 1525

Recombinant Mouse Clarin-1 (Clrn1)
MBS7011656-01mg	MyBiosource	0.1mg	EUR 2485

Recombinant Mouse Clarin-1 (Clrn1)
MBS7011656-5x01mg	MyBiosource	5x0.1mg	EUR 11145

CLRN1 (untagged)-Human clarin 1 (CLRN1), transcript variant 4
SC305711	Origene Technologies GmbH	10 µg	Ask for price

CLRN1 (untagged) - Human clarin 1 (CLRN1), transcript variant 6
SC334273	Origene Technologies GmbH	10 µg	Ask for price

Lenti ORF clone of Clrn1 (mGFP-tagged ORF) - Rat clarin 1 (Clrn1), (10 ug)
RR213201L4	Origene Technologies GmbH	10 µg	Ask for price

CLRN1 (GFP-tagged) - Human clarin 1 (CLRN1), transcript variant 1
RG210388	Origene Technologies GmbH	10 µg	Ask for price

Clrn1 (untagged) - Mouse clarin 1 (Clrn1), transcript variant 1, (10ug)
MC212849	Origene Technologies GmbH	10 µg	Ask for price

Rat Clarin 2(CLRN2) ELISA kit
E01A12054	BlueGene	96T	EUR 700
Description: ELISA

Rat Clarin 3(CLRN3) ELISA kit
E01A12055	BlueGene	96T	EUR 700
Description: ELISA

Rat Clarin 3 (CLRN3) ELISA Kit
abx507390-96tests	Abbexa	96 tests	EUR 687.5

Rat Clarin 2(CLRN2) ELISA kit
E02C1813-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Clarin 2(CLRN2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Clarin 2(CLRN2) ELISA kit
E02C1813-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Clarin 2(CLRN2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Clarin 2(CLRN2) ELISA kit
E02C1813-48wellsplate	BlueGene	48 wells plate	EUR 280

Rat Clarin 2(CLRN2) ELISA kit
E02C1813-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Clarin 2(CLRN2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Clarin 2(CLRN2) ELISA kit
E02C1813-96wellsplate	BlueGene	96 wells plate	EUR 405

Rat Clarin 3(CLRN3) ELISA kit
E02C1814-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Clarin 3(CLRN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Clarin 3(CLRN3) ELISA kit
E02C1814-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Clarin 3(CLRN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Clarin 3(CLRN3) ELISA kit
E02C1814-48wellsplate	BlueGene	48 wells plate	EUR 280

Rat Clarin 3(CLRN3) ELISA kit
E02C1814-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Clarin 3(CLRN3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Clarin 3(CLRN3) ELISA kit
E02C1814-96wellsplate	BlueGene	96 wells plate	EUR 405

Rat Clarin 3(CLRN3)ELISA Kit
GA-E0891RT-48T	GenAsia Biotech	48T	EUR 403.2

Rat Clarin 3(CLRN3)ELISA Kit
GA-E0891RT-48Tests	GenAsia Biotech	48 Tests	Ask for price

Rat Clarin 3(CLRN3)ELISA Kit
GA-E0891RT-96T	GenAsia Biotech	96T	EUR 640.8

Rat Clarin 3(CLRN3)ELISA Kit
GA-E0891RT-96Tests	GenAsia Biotech	96 Tests	EUR 460

Rat Clarin 3 (CLRN3) ELISA Kit
MBS9312693-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Rat Clarin 3 (CLRN3) ELISA Kit
MBS9312693-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Rat Clarin 3 (CLRN3) ELISA Kit
MBS9312693-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Rat Clarin 3 (CLRN3) ELISA Kit
MBS9312693-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Rat Clarin-3 (CLRN3) ELISA Kit
MBS283999-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6255

Rat Clarin-3 (CLRN3) ELISA Kit
MBS283999-48StripWells	MyBiosource	48-Strip-Wells	EUR 445

Rat Clarin-3 (CLRN3) ELISA Kit
MBS283999-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3290

Rat Clarin-3 (CLRN3) ELISA Kit
MBS283999-96StripWells	MyBiosource	96-Strip-Wells	EUR 730

Rat Clarin-2 (CLRN2) ELISA Kit
MBS7232041-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Rat Clarin-2 (CLRN2) ELISA Kit
MBS7232041-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Rat Clarin-2 (CLRN2) ELISA Kit
MBS7232041-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Rat Clarin-2 (CLRN2) ELISA Kit
MBS7232041-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Rat Clarin-3 (CLRN3) ELISA Kit
MBS7237014-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Rat Clarin-3 (CLRN3) ELISA Kit
MBS7237014-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Rat Clarin-3 (CLRN3) ELISA Kit
MBS7237014-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Rat Clarin-3 (CLRN3) ELISA Kit
MBS7237014-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

CLRN1 (GFP-tagged) - Human clarin 1 (CLRN1), transcript variant 4
RG218363	Origene Technologies GmbH	10 µg	Ask for price

CLRN1 (GFP-tagged) - Human clarin 1 (CLRN1), transcript variant 5
RG231092	Origene Technologies GmbH	10 µg	Ask for price

Lenti ORF clone of Clrn1 (Myc-DDK-tagged ORF) - Rat clarin 1 (Clrn1), (10 ug)
RR213201L3	Origene Technologies GmbH	10 µg	Ask for price

Clrn1 (untagged) - Mouse clarin 1 (Clrn1), transcript variant 3, (10ug)
MC212850	Origene Technologies GmbH	10 µg	Ask for price

Clrn1 (untagged) - Mouse clarin 1 (Clrn1), transcript variant 2, (10ug)
MC212851	Origene Technologies GmbH	10 µg	Ask for price

Recombinant Mouse Clarin-1 (Clrn1), partial
MBS7093000-INQUIRE	MyBiosource	INQUIRE	Ask for price

Recombinant Human Clarin-1 (CLRN1), partial
MBS952243-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 750

Recombinant Human Clarin-1 (CLRN1), partial
MBS952243-02mgYeast	MyBiosource	0.2mg(Yeast)	EUR 1005

Recombinant Human Clarin-1 (CLRN1), partial
MBS952243-05mgYeast	MyBiosource	0.5mg(Yeast)	EUR 1130

Recombinant Human Clarin-1 (CLRN1), partial
MBS952243-1mgYeast	MyBiosource	1mg(Yeast)	EUR 1650

Clrn1 (GFP-tagged) - Mouse clarin 1 (Clrn1) transcript variant 1, (10ug)
MG217495	Origene Technologies GmbH	10 µg	Ask for price

Clrn1 (Myc-DDK-tagged) - Mouse clarin 1 (Clrn1), transcript variant 1
MR217495	Origene Technologies GmbH	10 µg	Ask for price

CLRN1 (Myc-DDK-tagged)-Human clarin 1 (CLRN1), transcript variant 1
RC210388	Origene Technologies GmbH	10 µg	Ask for price

Lenti ORF particles, Clrn1 (GFP-tagged ORF) - Rat clarin 1 (Clrn1), 200ul, >10^7 TU/mL
RR213201L4V	Origene Technologies GmbH	200 µl	Ask for price

Clrn1 (GFP-tagged) - Mouse clarin 1 (Clrn1) transcript variant 2, (10ug)
MG218728	Origene Technologies GmbH	10 µg	Ask for price

Clrn1 (GFP-tagged) - Mouse clarin 1 (Clrn1) transcript variant 3, (10ug)
MG215940	Origene Technologies GmbH	10 µg	Ask for price

Clrn1 (Myc-DDK-tagged) - Mouse clarin 1 (Clrn1), transcript variant 3
MR215940	Origene Technologies GmbH	10 µg	Ask for price

Clrn1 (Myc-DDK-tagged) - Mouse clarin 1 (Clrn1), transcript variant 2
MR218728	Origene Technologies GmbH	10 µg	Ask for price

CLRN1 (Myc-DDK-tagged)-Human clarin 1 (CLRN1), transcript variant 4
RC218363	Origene Technologies GmbH	10 µg	Ask for price

CLRN1 (myc-DDK-tagged) - Human clarin 1 (CLRN1), transcript variant 6
RC236379	Origene Technologies GmbH	10 µg	Ask for price

Analizując korelację wartości SA w surowicy z glikemią i hemoglobiną glikowaną u chorych na cukrzycę, stwierdzono, że oba parametry wykazywały silną dodatnią korelację (P <0,0001) w grupie chorych na cukrzycę typu 2. Dlatego SA można uznać za potencjalny marker do badań przesiewowych, diagnostyki lub prognozowania cukrzycy typu 2 u kobiet po menopauzie.