Różnice w poziomie ekspresji mRNA genów epimerazy UDP-GlcNAc / kinazy ManNAc i neuraminidazy 1 w narządach zwierząt z cukrzycą typu 2

Kwas sialowy i związane z nim enzymy metaboliczne okazały się ważnymi składnikami patofizjologii cukrzycy typu 2 (T2D). U ludzi i zwierząt z T2D występuje podwyższenie stężenia kwasu sialowego w surowicy. W niniejszym badaniu zbadano modulację poziomu ekspresji mRNA genów UDP-N-acetyloglukozamino-2-epimerazy / kinazy N-acetylomannozaminy (GNE) i neuraminidazy 1 (NEU1) w niektórych narządach szczurów z cukrzycą typu 2.

T2D indukowano za pomocą modelu fruktozy-streptozotocyny i osiem tygodni po wywołaniu cukrzycy oznaczano kwas sialowy we krwi i narządach (tkance tłuszczowej, mózgu, okrężnicy, nerkach, wątrobie, trzustce, mięśniach szkieletowych i śledzionie), a następnie oznaczono ilościowo mRNA poziom ekspresji genów GNE i NEU1 przez qPCR. Wyniki wykazały znaczący (P <0,05) wzrost poziomu kwasu sialowego w surowicy i we wszystkich wyżej wymienionych badanych narządach z wyjątkiem tkanki tłuszczowej i mięśni szkieletowych szczurów z cukrzycą w porównaniu z normalną grupą kontrolną.

Ekspresja genu GNE była zwiększona tylko w trzustce (1,8-krotnie) u szczurów z cukrzycą, podczas gdy nastąpiło zmniejszenie ekspresji genu w okrężnicy. Natomiast ekspresja genu NEU1 wzrosła w śledzionie (3,5-krotnie), mózgu (2,2-krotnie), wątrobie (1,9-krotnie), okrężnicy (1,5-krotnie) i nerkach szczurów z cukrzycą. Stwierdzono, że podwyższony poziom kwasu sialowego w narządach szczurów z cukrzycą, z wyjątkiem trzustki, może nie wynikać ze zwiększonej endogennej syntezy kwasu sialowego.

Jak aktywność sportowa wiąże się ze śmiertelnością, cukrzycą i stanem przedcukrzycowym dla różnych poziomów wskaźnika masy ciała?

W niniejszym badaniu zbadano związek aktywności sportowej z wynikami zdrowotnymi i czy związek ten różni się między subpopulacjami na poziomie wskaźnika masy ciała (BMI). Wyniki badań dotyczące aktywności sportowej porównano z innymi rodzajami aktywności fizycznej w czasie wolnym (PA). Zastosowaliśmy modele regresji proporcjonalnych hazardów Coxa do oceny związków między uprawianiem sportu i czterema innymi typami PA (jazda na rowerze, ogrodnictwo, wykonywanie dorywczych prac i chodzenie), z ryzykiem wystąpienia stanu przedcukrzycowego, cukrzycy typu 2 (T2DM) i śmiertelności z jakiejkolwiek przyczyny u 97 212 osób (58,4% kobiet; średni wiek: 46,5 lat) w kohorcie holenderskich Lifelines.

Wyniki zostały stratyfikowane według trzech poziomów BMI: zdrowej masy ciała (BMI 18,5-24,9 kg / m2), nadwagi (BMI 25,0-29,9 kg / m2) i otyłości (BMI 30,0 kg / m2 lub więcej). Aktywność sportowa wiązała się z mniejszym ryzykiem dla zdrowia, ale tylko istotnie w przypadku stanu przedcukrzycowego (HR = 0,86, 95% CI 0,81 do 0,92). W przypadku osób o zdrowej masie ciała aktywność sportowa wiązała się z największym zmniejszeniem ryzyka, przy znacznie niższym ryzyku wystąpienia stanu przedcukrzycowego (HR = 0,78, 95% CI 0,68 do 0,90) i śmiertelności z dowolnej przyczyny (HR = 0,79, 95% CI 0,65 do 0,96) .

Inne typy PA nie wiązały się z istotnie niższymi zagrożeniami dla zdrowia, z wyjątkiem jazdy na rowerze, w przypadku której stwierdzono znacznie mniejsze zagrożenie dla zdrowia osób z nadwagą. Nasze odkrycia pokazują, że aktywność sportowa wiąże się z mniejszym zagrożeniem dla zdrowia, zwłaszcza stanem przedcukrzycowym, ale wpływ różni się w zależności od poziomu BMI, przy czym najsilniejszy związek występuje u osób o zdrowej wadze. Udział w sporcie, wraz z jazdą na rowerze, prawdopodobnie będzie skuteczniejszy w zmniejszaniu zagrożeń dla zdrowia niż inne rodzaje PA.

miR-139-5p promuje neowaskularyzację w retinopatii cukrzycowej poprzez regulację fosfatazy i homologu tensyny

Patologiczna neowaskularyzacja siatkówki jest motorem postępu retinopatii cukrzycowej (DR). Niniejsze badanie miało na celu zidentyfikowanie mikroRNA (miRNA), które ulegają zróżnicowanej ekspresji podczas progresji DR, a także zbadanie specyficznego mechanizmu regulacyjnego tych miRNA w neowaskularyzacji siatkówkowej. Korzystając z zestawu danych z mikromacierzy i mysiego modelu z cukrzycą, określono, że miR-139-5p był znacznie zwiększony podczas progresji DR. Badanie in vitro ujawniło podwyższenie poziomu miR-139-5p zarówno w komórkach śródbłonka mikronaczyniowego siatkówki myszy (mRMEC) leczonych wysokim poziomem glukozy (HG), jak iw ludzkich RMEC traktowanych HG (hRMEC).

Nadekspresja miR-139-5p zwiększała migrację komórek, ułatwiała tworzenie rurek i zwiększała poziom białka czynnika wzrostu śródbłonka naczyniowego (VEGF) w hRMEC. Podczas gdy efekt angiogenny nadekspresji miR-139-5p został zatrzymany przez przeciwciało anty-VEGF. W międzyczasie knockdown miR-139-5p wyeliminował migrację komórek indukowaną przez VEGF i tworzenie rurek w hRMEC. Homolog fosfatazy i tensyny (PTEN) był docelowym genem miR-139-5p.

Nadekspresja PTEN usunęła angiogenny wpływ nadekspresji miR-139-5p, co doprowadziło do zmniejszenia migracji komórek i tworzenia rurek. U myszy z cukrzycą miR-139-5p antagomir skutecznie zmniejszał bezkomórkowe naczynia włosowate i hamował tworzenie nieprawidłowych naczyń krwionośnych w tkankach siatkówki. Podsumowując, miR-139-5p promuje neowaskularyzację siatkówki poprzez tłumienie ekspresji PTEN.

50 lat behawioralnej nauki w cukrzycy: wizja przyszłości 2020

Ten artykuł powstał na podstawie przemówienia, które dr de Groot wygłosił w czerwcu 2020 r. Jako prezes ds. Opieki zdrowotnej i edukacji American Diabetes Association podczas 80. sesji naukowych Stowarzyszenia, które odbyło się online w wyniku choroby koronawirusowej 2019 r. Dr. de Groot jest profesorem nadzwyczajnym medycyny na Wydziale Endokrynologii, Cukrzycy i Metabolizmu w Szkole Medycznej Uniwersytetu Indiana (IU). Pełni funkcję po dyrektora IU Diabetes Translational Research Center.

Dr de Groot jest laureatem medalu Rachmiel Levine za przywództwo w 2020 roku od American Diabetes Association. W tym stosunkowo krótkim czasie w tej dziedzinie przedstawiono psychospołeczny krajobraz stanu przedcukrzycowego i cukrzycy poprzez ustalenie częstości występowania i wpływu emocjonalnych i behawioralnych aspektów cukrzycy.

Opracowano interwencje mające na celu rozwiązanie tych schorzeń, które obejmują zakres badań translacyjnych od T2 do T4, od interwencji intrapsychicznych do interwencji populacyjnych. Wdrożono różne zasady, od standardów opieki po świadczenia Medicare. Jako przykład innowacji w tej dziedzinie podano przegląd badań dotyczących cukrzycy i depresji.

ELISA kit for Human Transcriptional repressor protein YY1 (YY1)
KTE60006-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Transcriptional repressor protein YY1 (YY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional repressor protein YY1 (YY1)
KTE60006-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human Transcriptional repressor protein YY1 (YY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human Transcriptional activator protein Pur-beta (PURB) ELISA Kit
abx385326-96tests	Abbexa	96 tests	EUR 1093.2

Mouse Transcriptional repressor protein YY1, Yy1 ELISA KIT
ELI-51320m	Lifescience Market	96 Tests	EUR 1038

Human Transcriptional adapter 1, TADA1 ELISA KIT
ELI-29230h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional adapter 3, TADA3 ELISA KIT
ELI-53341h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional Adaptor 3(TADA3)ELISA Kit
QY-E00094	Qayee Biotechnology	96T	EUR 433.2

Human Transcriptional Adaptor 1(TADA1)ELISA Kit
QY-E00095	Qayee Biotechnology	96T	EUR 433.2

Human Transcriptional activator Myb (MYB) ELISA Kit
abx250446-96tests	Abbexa	96 tests	EUR 801.6

Human Transcriptional Regulator ERG (ERG) ELISA Kit
abx387181-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional Adaptor 1 (TADA1L) ELISA Kit
abx383613-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional Adaptor 2B (TADA2B) ELISA Kit
abx383614-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional Adaptor 2A (TADA2L) ELISA Kit
abx383615-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional Adaptor 3 (TADA3L) ELISA Kit
abx383616-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb(MYB) ELISA kit
E01T0632-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb(MYB) ELISA kit
E01T0632-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb(MYB) ELISA kit
E01T0632-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb, MYB ELISA KIT
ELI-03421h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional regulator ERG, ERG ELISA KIT
ELI-10025h	Lifescience Market	96 Tests	EUR 988.8

Human MYB/ Transcriptional activator Myb ELISA Kit
E1682Hu	Sunlong	1 Kit	EUR 685.2

Human MYB(Transcriptional activator Myb) ELISA Kit
EH1192	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human ERG(Transcriptional regulator ERG) ELISA Kit
EH4920	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human Transcriptional repressor CTCF (CTCF) ELISA Kit
abx520116-96tests	Abbexa	96 tests	EUR 801.6

Human Transcriptional repressor CTCF(CTCF) ELISA kit
E01T0609-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional repressor CTCF(CTCF) ELISA kit
E01T0609-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional repressor CTCF(CTCF) ELISA kit
E01T0609-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator GLI3(GLI3) ELISA kit
E01T0618-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator GLI3(GLI3) ELISA kit
E01T0618-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator GLI3(GLI3) ELISA kit
E01T0618-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator GLI3, GLI3 ELISA KIT
ELI-09540h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional repressor CTCF, CTCF ELISA KIT
ELI-07426h	Lifescience Market	96 Tests	EUR 988.8

ELISA kit for Human Transcriptional repressor CTCFL
EK4530	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Transcriptional repressor CTCFL in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Transcriptional regulator ATRX, ATRX ELISA KIT
ELI-25220h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional repressor NF- X1, NFX1 ELISA KIT
ELI-23614h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional repressor CTCFL (CTCFL) ELISA Kit
abx251577-96tests	Abbexa	96 tests	EUR 801.6

Human Transcriptional repressor CTCFL, CTCFL ELISA KIT
ELI-09988h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional regulator Kaiso (ZBTB33) ELISA Kit
abx385521-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional regulator Kaiso, ZBTB33 ELISA KIT
ELI-08145h	Lifescience Market	96 Tests	EUR 988.8

Rat Transcriptional activator protein Pur-beta (PURB) ELISA Kit
abx391871-96tests	Abbexa	96 tests	EUR 1093.2

Purb ELISA Kit| Rat Transcriptional activator protein Pur-beta
EF019231	Lifescience Market	96 Tests	EUR 826.8

Human MIER1 Transcriptional Regulator (MIER1) ELISA Kit
abx381449-96tests	Abbexa	96 tests	EUR 1093.2

Human CTCFL(Transcriptional repressor CTCFL) ELISA Kit
EH2232	FN Test	96T	EUR 681.12
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human YAP1/ Transcriptional coactivator YAP1 ELISA Kit
E2705Hu	Sunlong	1 Kit	EUR 726

Human CTCFL/ Transcriptional repressor CTCFL ELISA Kit
E2764Hu	Sunlong	1 Kit	EUR 685.2

Human Transcriptional adapter 2- beta, TADA2B ELISA KIT
ELI-46305h	Lifescience Market	96 Tests	EUR 988.8

Purb ELISA Kit| Mouse Transcriptional activator protein Pur-bet
EF016000	Lifescience Market	96 Tests	EUR 826.8

ELISA kit for Human Transcriptional regulator ATRX (ATRX)
KTE62202-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human Transcriptional regulator ATRX (ATRX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional regulator ATRX (ATRX)
KTE62202-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Transcriptional regulator ATRX (ATRX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional regulator ATRX (ATRX)
KTE62202-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human Transcriptional regulator ATRX (ATRX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human Transcriptional adapter 2- alpha, TADA2A ELISA KIT
ELI-41683h	Lifescience Market	96 Tests	EUR 988.8

Mouse Transcriptional activator protein Pur-beta (PURB) ELISA Kit
abx390359-96tests	Abbexa	96 tests	EUR 1093.2

Transcriptional Adaptor 3 Protein
20-abx262696	Abbexa	EUR 393.60 EUR 7676.40 EUR 276.00	10 ug 1 mg 2 µg

Human SKI family transcriptional corepressor 1, SKOR1 ELISA KIT
ELI-29593h	Lifescience Market	96 Tests	EUR 988.8

Human SKI family transcriptional corepressor 2, SKOR2 ELISA KIT
ELI-29833h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional repressor scratch 2, SCRT2 ELISA KIT
ELI-39287h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional repressor scratch 1, SCRT1 ELISA KIT
ELI-29440h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional repressor p66- beta, GATAD2B ELISA KIT
ELI-14553h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional- regulating factor 1, TRERF1 ELISA KIT
ELI-45739h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional repressor p66- alpha, GATAD2A ELISA KIT
ELI-21803h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional Repressor P66-Beta (GATAD2B) ELISA Kit
abx387502-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional enhancer factor TEF- 3, TEAD4 ELISA KIT
ELI-52111h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional enhancer factor TEF 5(TEAD3) ELISA kit
E01T0674-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Transcriptional enhancer factor TEF 5(TEAD3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional enhancer factor TEF 5(TEAD3) ELISA kit
E01T0674-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Transcriptional enhancer factor TEF 5(TEAD3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional enhancer factor TEF 5(TEAD3) ELISA kit
E01T0674-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Transcriptional enhancer factor TEF 5(TEAD3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional enhancer factor TEF 3(TEAD4) ELISA kit
E01T0675-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Transcriptional enhancer factor TEF 3(TEAD4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional enhancer factor TEF 3(TEAD4) ELISA kit
E01T0675-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Transcriptional enhancer factor TEF 3(TEAD4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional enhancer factor TEF 3(TEAD4) ELISA kit
E01T0675-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Transcriptional enhancer factor TEF 3(TEAD4) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional enhancer factor TEF- 1, TEAD1 ELISA KIT
ELI-37087h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional enhancer factor TEF- 5, TEAD3 ELISA KIT
ELI-37088h	Lifescience Market	96 Tests	EUR 988.8

Human Transcriptional enhancer factor TEF- 4, TEAD2 ELISA KIT
ELI-29025h	Lifescience Market	96 Tests	EUR 988.8

Human SUB1 Homolog, Transcriptional Regulator (SUB1) ELISA Kit
abx383553-96tests	Abbexa	96 tests	EUR 1093.2

Human MN1 Proto-Oncogene, Transcriptional Regulator (MN1) ELISA Kit
abx381479-96tests	Abbexa	96 tests	EUR 1093.2

Human MN1 Proto-Oncogene, Transcriptional Regulator (MN1) ELISA Kit
abx595816-96tests	Abbexa	96 tests	EUR 764.4

Human Ovo Like Transcriptional Repressor 1 (OVOL1) ELISA Kit
abx382004-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional-Regulating Factor 1 (TRERF1) ELISA Kit
abx383915-96tests	Abbexa	96 tests	EUR 1093.2

Human Transcriptional Regulating Factor 1 (TRERF1) Protein
20-abx650190	Abbexa	EUR 744.00 EUR 326.40 EUR 2230.80 EUR 878.40 EUR 543.60	100 ug 10 ug 1 mg 200 ug 50 ug

TADA3 Transcriptional Adaptor 3 Human Recombinant Protein
PROTO75528	BosterBio	Regular: 10ug	EUR 380.4
Description: TADA3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 455 amino acids (1-432) and having a molecular mass of 51.3 kDa.;TADA3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Human Snail Family Transcriptional Repressor 3 (SNAI3) ELISA Kit
abx383331-96tests	Abbexa	96 tests	EUR 1093.2

ELISA kit for Human Transcriptional enhancer factor TEF-1 (TEAD1)
KTE60503-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human Transcriptional enhancer factor TEF-1 (TEAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional enhancer factor TEF-1 (TEAD1)
KTE60503-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human Transcriptional enhancer factor TEF-1 (TEAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional enhancer factor TEF-1 (TEAD1)
KTE60503-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human Transcriptional enhancer factor TEF-1 (TEAD1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Cow Transcriptional Activator Myb (MYB) ELISA Kit
abx514935-96tests	Abbexa	96 tests	EUR 1093.2

Dog Transcriptional regulator ERG(ERG) ELISA kit
E08T0612-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Transcriptional regulator ERG(ERG) ELISA kit
E08T0612-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Transcriptional regulator ERG(ERG) ELISA kit
E08T0612-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Transcriptional activator Myb(MYB) ELISA kit
E08T0632-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Transcriptional activator Myb(MYB) ELISA kit
E08T0632-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Transcriptional activator Myb(MYB) ELISA kit
E08T0632-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional regulator ERG(ERG) ELISA kit
E02T0612-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional regulator ERG(ERG) ELISA kit
E02T0612-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional regulator ERG(ERG) ELISA kit
E02T0612-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional activator Myb(MYB) ELISA kit
E02T0632-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional activator Myb(MYB) ELISA kit
E02T0632-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional activator Myb(MYB) ELISA kit
E02T0632-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Transcriptional regulator ERG(ERG) ELISA kit
E07T0612-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Transcriptional regulator ERG(ERG) ELISA kit
E07T0612-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Transcriptional regulator ERG(ERG) ELISA kit
E07T0612-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Transcriptional activator Myb(MYB) ELISA kit
E07T0632-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Transcriptional activator Myb(MYB) ELISA kit
E07T0632-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Transcriptional activator Myb(MYB) ELISA kit
E07T0632-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Transcriptional regulator ERG(ERG) ELISA kit
E06T0612-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Transcriptional regulator ERG(ERG) ELISA kit
E06T0612-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Transcriptional regulator ERG(ERG) ELISA kit
E06T0612-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Transcriptional activator Myb(MYB) ELISA kit
E06T0632-192T	BlueGene	192 tests	EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Transcriptional activator Myb(MYB) ELISA kit
E06T0632-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Transcriptional activator Myb(MYB) ELISA kit
E06T0632-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Transcriptional adapter 3, Tada3 ELISA KIT
ELI-41644m	Lifescience Market	96 Tests	EUR 1038

Mouse Transcriptional adapter 1, Tada1 ELISA KIT
ELI-53083m	Lifescience Market	96 Tests	EUR 1038

Recombinant human Transcriptional activator protein Pur-alpha
P2770	FN Test	100ug	Ask for price
Description: Recombinant protein for human Transcriptional activator protein Pur-alpha

Mouse Transcriptional Activator Myb (MYB) ELISA Kit
abx514938-96tests	Abbexa	96 tests	EUR 801.6

Rat Transcriptional repressor CTCF (CTCF) ELISA Kit
abx520118-96tests	Abbexa	96 tests	EUR 801.6

Dog Transcriptional repressor CTCF(CTCF) ELISA kit
E08T0609-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Transcriptional repressor CTCF(CTCF) ELISA kit
E08T0609-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Zachowanie jest podstawą wszystkich interwencji w cukrzycy i stanach przedcukrzycowych. Jako dojrzała nauka ma kluczowe znaczenie dla powstrzymania fali cukrzycy i jej następstw. Aby poczynić dodatkowe postępy, musimy zrównoważyć naszą koncentrację i zwiększyć finansowanie interwencji behawioralnych dla osób, społeczności i systemów opieki zdrowotnej w połączeniu z innymi formami leczenia.