Różnice w poziomie ekspresji mRNA genów epimerazy UDP-GlcNAc / kinazy ManNAc i neuraminidazy 1 w narządach zwierząt z cukrzycą typu 2

Kwas sialowy i związane z nim enzymy metaboliczne okazały się ważnymi składnikami patofizjologii cukrzycy typu 2 (T2D). U ludzi i zwierząt z T2D występuje podwyższenie stężenia kwasu sialowego w surowicy. W niniejszym badaniu zbadano modulację poziomu ekspresji mRNA genów UDP-N-acetyloglukozamino-2-epimerazy / kinazy N-acetylomannozaminy (GNE) i neuraminidazy 1 (NEU1) w niektórych narządach szczurów z cukrzycą typu 2.

T2D indukowano za pomocą modelu fruktozy-streptozotocyny i osiem tygodni po wywołaniu cukrzycy oznaczano kwas sialowy we krwi i narządach (tkance tłuszczowej, mózgu, okrężnicy, nerkach, wątrobie, trzustce, mięśniach szkieletowych i śledzionie), a następnie oznaczono ilościowo mRNA poziom ekspresji genów GNE i NEU1 przez qPCR. Wyniki wykazały znaczący (P <0,05) wzrost poziomu kwasu sialowego w surowicy i we wszystkich wyżej wymienionych badanych narządach z wyjątkiem tkanki tłuszczowej i mięśni szkieletowych szczurów z cukrzycą w porównaniu z normalną grupą kontrolną.

Ekspresja genu GNE była zwiększona tylko w trzustce (1,8-krotnie) u szczurów z cukrzycą, podczas gdy nastąpiło zmniejszenie ekspresji genu w okrężnicy. Natomiast ekspresja genu NEU1 wzrosła w śledzionie (3,5-krotnie), mózgu (2,2-krotnie), wątrobie (1,9-krotnie), okrężnicy (1,5-krotnie) i nerkach szczurów z cukrzycą. Stwierdzono, że podwyższony poziom kwasu sialowego w narządach szczurów z cukrzycą, z wyjątkiem trzustki, może nie wynikać ze zwiększonej endogennej syntezy kwasu sialowego.

Jak aktywność sportowa wiąże się ze śmiertelnością, cukrzycą i stanem przedcukrzycowym dla różnych poziomów wskaźnika masy ciała?

W niniejszym badaniu zbadano związek aktywności sportowej z wynikami zdrowotnymi i czy związek ten różni się między subpopulacjami na poziomie wskaźnika masy ciała (BMI). Wyniki badań dotyczące aktywności sportowej porównano z innymi rodzajami aktywności fizycznej w czasie wolnym (PA). Zastosowaliśmy modele regresji proporcjonalnych hazardów Coxa do oceny związków między uprawianiem sportu i czterema innymi typami PA (jazda na rowerze, ogrodnictwo, wykonywanie dorywczych prac i chodzenie), z ryzykiem wystąpienia stanu przedcukrzycowego, cukrzycy typu 2 (T2DM) i śmiertelności z jakiejkolwiek przyczyny u 97 212 osób (58,4% kobiet; średni wiek: 46,5 lat) w kohorcie holenderskich Lifelines.

Wyniki zostały stratyfikowane według trzech poziomów BMI: zdrowej masy ciała (BMI 18,5-24,9 kg / m2), nadwagi (BMI 25,0-29,9 kg / m2) i otyłości (BMI 30,0 kg / m2 lub więcej). Aktywność sportowa wiązała się z mniejszym ryzykiem dla zdrowia, ale tylko istotnie w przypadku stanu przedcukrzycowego (HR = 0,86, 95% CI 0,81 do 0,92). W przypadku osób o zdrowej masie ciała aktywność sportowa wiązała się z największym zmniejszeniem ryzyka, przy znacznie niższym ryzyku wystąpienia stanu przedcukrzycowego (HR = 0,78, 95% CI 0,68 do 0,90) i śmiertelności z dowolnej przyczyny (HR = 0,79, 95% CI 0,65 do 0,96) .

Inne typy PA nie wiązały się z istotnie niższymi zagrożeniami dla zdrowia, z wyjątkiem jazdy na rowerze, w przypadku której stwierdzono znacznie mniejsze zagrożenie dla zdrowia osób z nadwagą. Nasze odkrycia pokazują, że aktywność sportowa wiąże się z mniejszym zagrożeniem dla zdrowia, zwłaszcza stanem przedcukrzycowym, ale wpływ różni się w zależności od poziomu BMI, przy czym najsilniejszy związek występuje u osób o zdrowej wadze. Udział w sporcie, wraz z jazdą na rowerze, prawdopodobnie będzie skuteczniejszy w zmniejszaniu zagrożeń dla zdrowia niż inne rodzaje PA.

miR-139-5p promuje neowaskularyzację w retinopatii cukrzycowej poprzez regulację fosfatazy i homologu tensyny

Patologiczna neowaskularyzacja siatkówki jest motorem postępu retinopatii cukrzycowej (DR). Niniejsze badanie miało na celu zidentyfikowanie mikroRNA (miRNA), które ulegają zróżnicowanej ekspresji podczas progresji DR, a także zbadanie specyficznego mechanizmu regulacyjnego tych miRNA w neowaskularyzacji siatkówkowej. Korzystając z zestawu danych z mikromacierzy i mysiego modelu z cukrzycą, określono, że miR-139-5p był znacznie zwiększony podczas progresji DR. Badanie in vitro ujawniło podwyższenie poziomu miR-139-5p zarówno w komórkach śródbłonka mikronaczyniowego siatkówki myszy (mRMEC) leczonych wysokim poziomem glukozy (HG), jak iw ludzkich RMEC traktowanych HG (hRMEC).

Nadekspresja miR-139-5p zwiększała migrację komórek, ułatwiała tworzenie rurek i zwiększała poziom białka czynnika wzrostu śródbłonka naczyniowego (VEGF) w hRMEC. Podczas gdy efekt angiogenny nadekspresji miR-139-5p został zatrzymany przez przeciwciało anty-VEGF. W międzyczasie knockdown miR-139-5p wyeliminował migrację komórek indukowaną przez VEGF i tworzenie rurek w hRMEC. Homolog fosfatazy i tensyny (PTEN) był docelowym genem miR-139-5p.

Nadekspresja PTEN usunęła angiogenny wpływ nadekspresji miR-139-5p, co doprowadziło do zmniejszenia migracji komórek i tworzenia rurek. U myszy z cukrzycą miR-139-5p antagomir skutecznie zmniejszał bezkomórkowe naczynia włosowate i hamował tworzenie nieprawidłowych naczyń krwionośnych w tkankach siatkówki. Podsumowując, miR-139-5p promuje neowaskularyzację siatkówki poprzez tłumienie ekspresji PTEN.

50 lat behawioralnej nauki w cukrzycy: wizja przyszłości 2020

Ten artykuł powstał na podstawie przemówienia, które dr de Groot wygłosił w czerwcu 2020 r. Jako prezes ds. Opieki zdrowotnej i edukacji American Diabetes Association podczas 80. sesji naukowych Stowarzyszenia, które odbyło się online w wyniku choroby koronawirusowej 2019 r. Dr. de Groot jest profesorem nadzwyczajnym medycyny na Wydziale Endokrynologii, Cukrzycy i Metabolizmu w Szkole Medycznej Uniwersytetu Indiana (IU). Pełni funkcję po dyrektora IU Diabetes Translational Research Center.

Dr de Groot jest laureatem medalu Rachmiel Levine za przywództwo w 2020 roku od American Diabetes Association. W tym stosunkowo krótkim czasie w tej dziedzinie przedstawiono psychospołeczny krajobraz stanu przedcukrzycowego i cukrzycy poprzez ustalenie częstości występowania i wpływu emocjonalnych i behawioralnych aspektów cukrzycy.

Opracowano interwencje mające na celu rozwiązanie tych schorzeń, które obejmują zakres badań translacyjnych od T2 do T4, od interwencji intrapsychicznych do interwencji populacyjnych. Wdrożono różne zasady, od standardów opieki po świadczenia Medicare. Jako przykład innowacji w tej dziedzinie podano przegląd badań dotyczących cukrzycy i depresji.

C1orf26 Antibody
abx231063-100ug	Abbexa	100 ug	EUR 509
Shipped within 5-12 working days.

anti- C1orf26 antibody
FNab01063	FN Test	100µg	EUR 548.75
Immunogen: chromosome 1 open reading frame 26 Uniprot ID: Q5T5J6 Research Area: Developmental biology
Description: Antibody raised against C1orf26

Anti-C1orf26 antibody
PAab01063	Lifescience Market	100 ug	EUR 386

SWT1 siRNA
20-abx935750	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol
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SWT1 siRNA
20-abx935751	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol
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Human SWT1 shRNA Plasmid
20-abx960242	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg
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C1orf26 sgRNA CRISPR Lentivector set (Human)
K0205101	ABM	3 x 1.0 ug	EUR 339

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed
ELISA-1	Alpha Diagnostics	1	EUR 202

SWT1 ORF Vector (Human) (pORF)
ORF033577	ABM	1.0 ug DNA	Ask for price

SWT1 Protein Vector (Human) (pPB-C-His)
PV134306	ABM	500 ng	Ask for price

SWT1 Protein Vector (Human) (pPB-N-His)
PV134307	ABM	500 ng	Ask for price

SWT1 Protein Vector (Human) (pPM-C-HA)
PV134308	ABM	500 ng	Ask for price

SWT1 Protein Vector (Human) (pPM-C-His)
PV134309	ABM	500 ng	Ask for price

Human Transcriptional repressor protein YY1(YY1) ELISA kit
CSB-EL026297HU-24T	Cusabio	1 plate of 24 wells	EUR 165
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Transcriptional repressor protein YY1 (YY1) in samples from serum, plasma, cell culture supernates, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Transcriptional repressor protein YY1(YY1) ELISA kit
1-CSB-EL026297HU	Cusabio	EUR 804.00 EUR 5099.00 EUR 2704.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Sample volume: 50-100ul Detection wavelength: 450nm Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Transcriptional repressor protein YY1(YY1) in samples from serum, plasma, cell culture supernates, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Transcriptional repressor protein YY1, YY1 ELISA KIT
ELI-51868h	Lifescience Market	96 Tests	EUR 824

C1orf26 sgRNA CRISPR Lentivector (Human) (Target 1)
K0205102	ABM	1.0 ug DNA	EUR 154

C1orf26 sgRNA CRISPR Lentivector (Human) (Target 2)
K0205103	ABM	1.0 ug DNA	EUR 154

C1orf26 sgRNA CRISPR Lentivector (Human) (Target 3)
K0205104	ABM	1.0 ug DNA	EUR 154

Mouse SWT1 shRNA Plasmid
20-abx975832	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg
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Human Chromosome 1 Open Reading Frame 26 (SWT1) ELISA Kit
abx386173-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

SWT1 sgRNA CRISPR Lentivector set (Human)
K2809101	ABM	3 x 1.0 ug	EUR 339

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit
CAS400A-KIT	SBI	1 kit (10 rxn)	EUR 1110
Category: Cas9

Human Transcriptional repressor CTCF(CTCF) ELISA kit
E01T0609-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional repressor CTCF(CTCF) ELISA kit
E01T0609-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional repressor CTCF(CTCF) ELISA kit
E01T0609-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator GLI3(GLI3) ELISA kit
E01T0618-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator GLI3(GLI3) ELISA kit
E01T0618-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator GLI3(GLI3) ELISA kit
E01T0618-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Human Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb(MYB) ELISA kit
E01T0632-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A sandwich ELISA for quantitative measurement of Human Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb(MYB) ELISA kit
E01T0632-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A sandwich ELISA for quantitative measurement of Human Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb(MYB) ELISA kit
E01T0632-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A sandwich ELISA for quantitative measurement of Human Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional activator Myb (MYB) ELISA Kit
abx250446-96tests	Abbexa	96 tests	EUR 668
Shipped within 5-12 working days.

Human Transcriptional repressor CTCFL (CTCFL) ELISA Kit
abx251577-96tests	Abbexa	96 tests	EUR 668
Shipped within 5-12 working days.

Human CTCFL(Transcriptional repressor CTCFL) ELISA Kit
EH2232	FN Test	96T	EUR 567.6
Detection range: 0.312-20 ng/ml Uniprot ID: Q8NI51 Alias: CTCFL/Zinc finger protein CTCF-T/Cancer/testis antigen 27(CT27)/CTCF-like protein/CTCF paralog/Brother of the regulator of imprinted sites/CCCTC-binding factor
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human ERG(Transcriptional regulator ERG) ELISA Kit
EH4920	FN Test	96T	EUR 567.6
Detection range: 0.156-10 ng/ml
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

ELISA kit for Human Transcriptional repressor CTCFL
EK4530	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Transcriptional repressor CTCFL in samples from serum, plasma, tissue homogenates and other biological fluids.

Human MYB/ Transcriptional activator Myb ELISA Kit
E1682Hu	Sunlong	1 Kit	EUR 571

Human YAP1/ Transcriptional coactivator YAP1 ELISA Kit
E2705Hu	Sunlong	1 Kit	EUR 605

Human CTCFL/ Transcriptional repressor CTCFL ELISA Kit
E2764Hu	Sunlong	1 Kit	EUR 571

Human MYB(Transcriptional activator Myb) ELISA Kit
EH1192	FN Test	96T	EUR 567.6
Detection range: 0.156-10 ng/ml Uniprot ID: P10242 Alias: MYB/Transcriptional activator Myb/Proto-oncogene c-Myb
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human Transcriptional activator GLI3, GLI3 ELISA KIT
ELI-09540h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional repressor CTCFL, CTCFL ELISA KIT
ELI-09988h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional regulator ERG, ERG ELISA KIT
ELI-10025h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional regulator ATRX, ATRX ELISA KIT
ELI-25220h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional adapter 1, TADA1 ELISA KIT
ELI-29230h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional activator Myb, MYB ELISA KIT
ELI-03421h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional repressor CTCF, CTCF ELISA KIT
ELI-07426h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional regulator Kaiso, ZBTB33 ELISA KIT
ELI-08145h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional adapter 3, TADA3 ELISA KIT
ELI-53341h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional Adaptor 1 (TADA1L) ELISA Kit
abx383613-96tests	Abbexa	96 tests	EUR 911
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Human Transcriptional Adaptor 2B (TADA2B) ELISA Kit
abx383614-96tests	Abbexa	96 tests	EUR 911
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Human Transcriptional Adaptor 2A (TADA2L) ELISA Kit
abx383615-96tests	Abbexa	96 tests	EUR 911
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Human Transcriptional Adaptor 3 (TADA3L) ELISA Kit
abx383616-96tests	Abbexa	96 tests	EUR 911
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Human Transcriptional regulator Kaiso (ZBTB33) ELISA Kit
abx385521-96tests	Abbexa	96 tests	EUR 911
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Human MIER1 Transcriptional Regulator (MIER1) ELISA Kit
abx381449-96tests	Abbexa	96 tests	EUR 911
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Human Transcriptional repressor CTCF (CTCF) ELISA Kit
abx520116-96tests	Abbexa	96 tests	EUR 668
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Human Transcriptional Regulator ERG (ERG) ELISA Kit
abx387181-96tests	Abbexa	96 tests	EUR 911
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Human Transcriptional Adaptor 3(TADA3)ELISA Kit
QY-E00094	Qayee Biotechnology	96T	EUR 361

Human Transcriptional Adaptor 1(TADA1)ELISA Kit
QY-E00095	Qayee Biotechnology	96T	EUR 361

Human Transcriptional activator protein Pur-beta (PURB) ELISA Kit
abx385326-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

ELISA kit for Human Transcriptional repressor protein YY1 (YY1)
KTE60006-48T	Abbkine	48T	EUR 332
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone ace Show more
Description: Quantitative sandwich ELISA for measuring Human Transcriptional repressor protein YY1 (YY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional repressor protein YY1 (YY1)
KTE60006-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone ace Show more
Description: Quantitative sandwich ELISA for measuring Human Transcriptional repressor protein YY1 (YY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional repressor protein YY1 (YY1)
KTE60006-96T	Abbkine	96T	EUR 539
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone ace Show more
Description: Quantitative sandwich ELISA for measuring Human Transcriptional repressor protein YY1 (YY1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Swt1 ORF Vector (Rat) (pORF)
ORF077280	ABM	1.0 ug DNA	EUR 506

SWT1 Protein Vector (Rat) (pPB-C-His)
PV309118	ABM	500 ng	EUR 1166

SWT1 Protein Vector (Rat) (pPB-N-His)
PV309119	ABM	500 ng	EUR 1166

SWT1 Protein Vector (Rat) (pPM-C-HA)
PV309120	ABM	500 ng	EUR 1166

SWT1 Protein Vector (Rat) (pPM-C-His)
PV309121	ABM	500 ng	EUR 1166

Frit Kit
FRIT-KIT	Next Advance	1each	EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

SWT1 sgRNA CRISPR Lentivector (Human) (Target 1)
K2809102	ABM	1.0 ug DNA	EUR 154

SWT1 sgRNA CRISPR Lentivector (Human) (Target 2)
K2809103	ABM	1.0 ug DNA	EUR 154

SWT1 sgRNA CRISPR Lentivector (Human) (Target 3)
K2809104	ABM	1.0 ug DNA	EUR 154

Mouse Transcriptional repressor protein YY1, Yy1 ELISA KIT
ELI-51320m	Lifescience Market	96 Tests	EUR 865

Column Packing Kit
PACK-KIT	Next Advance	1pack	EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

C1orf26 3'UTR GFP Stable Cell Line
TU052007	ABM	1.0 ml	EUR 1394

C1orf26 3'UTR Luciferase Stable Cell Line
TU002007	ABM	1.0 ml	EUR 1394

Human Transcriptional repressor p66- beta, GATAD2B ELISA KIT
ELI-14553h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional repressor p66- alpha, GATAD2A ELISA KIT
ELI-21803h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional repressor NF- X1, NFX1 ELISA KIT
ELI-23614h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional repressor scratch 1, SCRT1 ELISA KIT
ELI-29440h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional- regulating factor 1, TRERF1 ELISA KIT
ELI-45739h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional adapter 2- beta, TADA2B ELISA KIT
ELI-46305h	Lifescience Market	96 Tests	EUR 824

Human SUB1 Homolog, Transcriptional Regulator (SUB1) ELISA Kit
abx383553-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

Human Transcriptional-Regulating Factor 1 (TRERF1) ELISA Kit
abx383915-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

Human Transcriptional Repressor P66-Beta (GATAD2B) ELISA Kit
abx387502-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

Human Transcriptional repressor scratch 2, SCRT2 ELISA KIT
ELI-39287h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional adapter 2- alpha, TADA2A ELISA KIT
ELI-41683h	Lifescience Market	96 Tests	EUR 824

ELISA kit for Human Transcriptional regulator ATRX (ATRX)
KTE62202-48T	Abbkine	48T	EUR 332
The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and Show more
Description: Quantitative sandwich ELISA for measuring Human Transcriptional regulator ATRX (ATRX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional regulator ATRX (ATRX)
KTE62202-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115
The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and Show more
Description: Quantitative sandwich ELISA for measuring Human Transcriptional regulator ATRX (ATRX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Transcriptional regulator ATRX (ATRX)
KTE62202-96T	Abbkine	96T	EUR 539
The protein encoded by ATRX contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and Show more
Description: Quantitative sandwich ELISA for measuring Human Transcriptional regulator ATRX (ATRX) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

PCR Mycoplasma Detection Kit
M034-Kit	TOKU-E	Kit	EUR 266

Transcriptional Adaptor 3 Protein
20-abx262696	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg
Shipped within 5-10 working days.

Swt1 sgRNA CRISPR Lentivector set (Rat)
K6674801	ABM	3 x 1.0 ug	EUR 339

Purb ELISA Kit| Rat Transcriptional activator protein Pur-beta
EF019231	Lifescience Market	96 Tests	EUR 689

Purb ELISA Kit| Mouse Transcriptional activator protein Pur-bet
EF016000	Lifescience Market	96 Tests	EUR 689

Rat Transcriptional activator protein Pur-beta (PURB) ELISA Kit
abx391871-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

Mouse Transcriptional activator protein Pur-beta (PURB) ELISA Kit
abx390359-96tests	Abbexa	96 tests	EUR 911
Shipped within 5-12 working days.

SWT1 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)
LV803815	ABM	1.0 ug DNA	EUR 920

SWT1 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)
LV803816	ABM	1.0 ug DNA	EUR 920

Ctcf ELISA Kit| Rat Transcriptional repressor CTCF ELISA Kit
EF018441	Lifescience Market	96 Tests	EUR 689

Yap1 ELISA Kit| Rat Transcriptional coactivator YAP1 ELISA Kit
EF019488	Lifescience Market	96 Tests	EUR 689

Ctcf ELISA Kit| Mouse Transcriptional repressor CTCF ELISA Kit
EF013373	Lifescience Market	96 Tests	EUR 689

Rat Transcriptional repressor CTCF(CTCF) ELISA kit
E02T0609-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional repressor CTCF(CTCF) ELISA kit
E02T0609-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional repressor CTCF(CTCF) ELISA kit
E02T0609-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional repressor CTCF(CTCF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional regulator ERG(ERG) ELISA kit
E02T0612-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional regulator ERG(ERG) ELISA kit
E02T0612-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional regulator ERG(ERG) ELISA kit
E02T0612-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional activator GLI3(GLI3) ELISA kit
E02T0618-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional activator GLI3(GLI3) ELISA kit
E02T0618-48	B-Gene	1 plate of 48 wells	EUR 520
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional activator GLI3(GLI3) ELISA kit
E02T0618-96	B-Gene	1 plate of 96 wells	EUR 685
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A competitive ELISA for quantitative measurement of Rat Transcriptional activator GLI3(GLI3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Transcriptional activator Myb(MYB) ELISA kit
E02T0632-192T	B-Gene	192 tests	EUR 1270
Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT Show more
Description: A sandwich ELISA for quantitative measurement of Rat Transcriptional activator Myb(MYB) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Zachowanie jest podstawą wszystkich interwencji w cukrzycy i stanach przedcukrzycowych. Jako dojrzała nauka ma kluczowe znaczenie dla powstrzymania fali cukrzycy i jej następstw. Aby poczynić dodatkowe postępy, musimy zrównoważyć naszą koncentrację i zwiększyć finansowanie interwencji behawioralnych dla osób, społeczności i systemów opieki zdrowotnej w połączeniu z innymi formami leczenia.