Aktualne trendy w strategiach terapeutycznych w leczeniu cukrzycy

Cukrzyca jest jedną z najszybciej rozwijających się chorób niezakaźnych. Cukrzyca jest spowodowana zniszczeniem komórek beta trzustki lub z insulinoopornością i charakteryzuje się hiperglikemią. Cukrzyca powoduje bardzo poważny kryzys gospodarczy, ponieważ rynek leków na cukrzycę rozwija się bardzo szybko. Nawet po przełomowych odkryciach naukowych, dostępności lepszej infrastruktury opieki zdrowotnej, wzroście poziomu umiejętności czytania i pisania, ciężar cukrzycy stale rozprzestrzenia się w różnych sekcjach na całym świecie, a zwłaszcza w krajach o niskich i średnich dochodach.

Niedawny rozwój odkryć naukowych zaowocował powstaniem szeregu nowych generacji leków przeciwcukrzycowych, takich jak sulfonylomocznik, biguanidy, tiazolidynodion, inhibitory alfa glukozydazy. Wszystkie te leki wykazały znaczące obniżenie poziomu glukozy we krwi. Opracowano również i opisano kilka nowych klas leków hipoglikemizujących, takich jak analogi GLP-1, inhibitory DPP-IV, inhibitory amyliny, receptory aktywowane przez proliferatory peroksysomów.

Istnieją pewne aktywne cząsteczki i substancje bioaktywne zostały oczyszczone z ziół i roślin, co dodaje wartości do wojny z cukrzycą. Te fitokomponenty zniweczyły rozwój leków i doprowadziły do ​​identyfikacji leków na cukrzycę. Przegląd koncentruje się również na niektórych krytycznych obszarach cukrzycy, ze szczególnym uwzględnieniem podejścia do leczenia cukrzycy opartego na statynach oraz terapii przeciwcukrzycowej nowej generacji opartej na komórkach macierzystych.

Otyłość, cukrzyca typu 2 i ryzyko raka

Otyłość i cukrzyca typu 2 są związane ze zwiększonym ryzykiem raka i stają się coraz częstsze. Nieprawidłowości metaboliczne, takie jak insulinooporność i dyslipidemia, są związane zarówno z otyłością, jak i cukrzycą typu 2 i mają wpływ na związek otyłość-rak. Zaproponowano wiele mechanizmów łączących otyłość i cukrzycę z progresją raka, w tym wzrost sygnalizacji insuliny / IGF-1, wychwytu i metabolizmu lipidów i glukozy, zmiany w profilu cytokin, chemokin i adipokin, a także zmiany w tkanka tłuszczowa bezpośrednio sąsiadująca z miejscami raka. Niniejszy przegląd ma na celu podsumowanie i przedstawienie aktualnych danych epidemiologicznych i mechanistycznych łączących otyłość i cukrzycę typu 2 z rakiem, ze szczególnym uwzględnieniem roli insuliny, lipidów i tkanki tłuszczowej.

Słodki i słony: cukrzycowa kwasica ketonowa u pacjenta z nefrogenną cukrzycą prostą

Współwystępowanie nefrogennej moczówki prostej (NDI) z cukrzycą (DM) u pacjenta z cukrzycową kwasicą ketonową (DKA) jest rzadkie i, według naszej wiedzy, nie zostało opisane nawet w opisach przypadków. Przedstawiamy przypadek 16-letniego mężczyzny ze znanym NDI, który zgłosił się na jeden dzień na oddział ratunkowy (SOR) u dzieci z uogólnionym osłabieniem i zmniejszonym apetytem, ​​u którego stwierdzono umiarkowaną CKK po pojawieniu się DM.

Początkowe leczenie odwodnienia i stanu hiperosmolarnego stanowiło wyjątkowe wyzwanie. Resuscytacja płynami izotonicznymi płynami u pacjenta z NDI stwarza ryzyko nasilenia hipernatremii, co może prowadzić do drgawek i śmierci. Jednak stosowanie płynów hipotonicznych może zbyt szybko obniżyć osmolalność surowicy, co może skutkować obrzękiem mózgu.

Konsultanci nefrologii, endokrynologii i pediatrycznego oddziału intensywnej opieki medycznej (PICU) zostali powiadomieni o tym pacjencie i skoordynowano dyskusję między pod-specjalistami w celu ustalenia odpowiedniej resuscytacji płynowej. Pacjentowi pozwolono pić bezpłatną wodę oprócz dożylnych płynów (IVF) 5% dekstrozy z 0,2% chlorkiem sodu z szybkością półtorej dawki podtrzymującej (150 ml / godz.) Na SOR przed transferem na OIT, gdzie rozpoczęto wlew insuliny. Ten opis przypadku zawiera wytyczne dla personelu szpitalnego dotyczące postępowania z pacjentami ze współistniejącymi NDI i DM w DKA, rzadkim połączeniu, które wymaga przemyślanego i pilnego leczenia.

Sygnatura mikroRNA osocza związana z retinopatią u pacjentów z cukrzycą typu 2

Retinopatia cukrzycowa (DR) jest główną przyczyną utraty wzroku i niepełnosprawności. Skuteczne leczenie DR zależy od szybkiego leczenia i przyniosłoby korzyści z biomarkerów do badań przesiewowych i przedobjawowego wykrywania retinopatii u pacjentów z cukrzycą. MikroRNA (miRNA) to post-transkrypcyjne regulatory ekspresji genów, które są uwalniane we krwi i mogą służyć jako biomarkery. Niewiele wiadomo na temat krążących miRNA u pacjentów z cukrzycą typu 2 (T2DM) i DR.

Tutaj pokazujemy, że DR jest związane z wyższym krążącym miR-25-3p (P = 0,004) i miR-320b (P = 0,011) oraz niższymi poziomami miR-495-3p (P <0,001) w kohorcie pacjentów z T2DM z DR (n = 20), w porównaniu z osobami z cukrzycą bez DR (n = 10) i osobami zdrowymi (n = 10). Zależności te utrzymywały się znaczące po dostosowaniu do wieku, płci i HbA1c. Poziomy krążących miRNA korelowały z ciężkością choroby, a ich towarzysząca ocena wykazała wysoką dokładność identyfikacji DR (AUROC = 0,93; P <0,001).

Analiza ontologii genów zweryfikowanych celów wykazała wzbogacenie szlaków, takich jak regulacja procesów metabolicznych (P = 1,5 × 10-20), odpowiedź komórek na stres (P = 1,9 × 10-14) i rozwój naczyń krwionośnych (P = 2,7 × 10-14). W oczekiwaniu na zewnętrzną walidację spodziewamy się, że te miRNA mogą służyć jako domniemane biomarkery choroby i uwydatniać nowe cele molekularne w celu poprawy opieki nad pacjentami z retinopatią cukrzycową.

Rola sygnalizacji receptora komórek T w rozwoju cukrzycy typu 1

Sygnalizacja receptora komórek T (TCR) wpływa na wiele aspektów immunobiologii limfocytów T CD4 + i CD8 +, w tym rozwój grasicy, homeostazę obwodową, różnicowanie / funkcję podzbiorów efektorowych i tworzenie pamięci. Dodatkowe wskazówki sygnalizacyjne komórek T wyzwalane przez cząsteczki kostymulujące i cytokiny również wpływają na czas trwania sygnalizacji TCR, a także dodatkowe szlaki, które dodatkowo kształtują odpowiedź komórek T.

Cukrzyca typu 1 (T1D) jest chorobą autoimmunologiczną kierowaną przez komórki T, której celem są komórki β trzustki wytwarzające insulinę. Dowody wskazują, że rozregulowane zdarzenia sygnalizacyjne TCR w T1D wpływają na skuteczność ośrodkowych i obwodowych mechanizmów wywołujących tolerancję.

TDP43 ELISA Kit| Mouse TAR DNA Binding Protein 43 ELISA Kit
EF013922	Lifescience Market	96 Tests	EUR 826.8

ELISA kit for Mouse TDP43 (TAR DNA Binding Protein 43)
E-EL-M1115	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse TDP43 (TAR DNA Binding Protein 43) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human TDP43 (TAR DNA Binding Protein 43)
E-EL-H0942	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human TDP43 (TAR DNA Binding Protein 43) in samples from Serum, Plasma, Cell supernatant

Tar DNA Binding Protein 43 kDa (TDP43) Antibody
20-abx103209	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Tar DNA Binding Protein 43 kDa (TDP43) Antibody
20-abx103210	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Tar DNA Binding Protein 43 kDa (TDP43) Antibody
20-abx174716	Abbexa	EUR 978.00 EUR 510.00	1 mg 200 ug

Human Tar DNA Binding Protein 43 kDa (TDP43) Protein
20-abx069231	Abbexa	EUR 828.00 EUR 343.20 EUR 2532.00 EUR 978.00 EUR 594.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Tar DNA Binding Protein 43 kDa (TDP43) Protein
20-abx069232	Abbexa	EUR 844.80 EUR 343.20 EUR 2598.00 EUR 994.80 EUR 594.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Tar DNA Binding Protein 43 kDa (TDP43) CLIA Kit
abx197753-96tests	Abbexa	96 tests	EUR 990

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
DLR-TDP43-Hu-48T	DL Develop	48T	EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in samples from serum, plasma, cerebrospinal fluid or other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
DLR-TDP43-Hu-96T	DL Develop	96T	EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in samples from serum, plasma, cerebrospinal fluid or other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
4-SEB951Hu	Cloud-Clone	EUR 5463.60 EUR 2886.00 EUR 735.60	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in samples from serum, plasma, cerebrospinal fluid and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RDR-TDP43-Hu-48Tests	Reddot Biotech	48 Tests	EUR 626.4

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RDR-TDP43-Hu-96Tests	Reddot Biotech	96 Tests	EUR 868.8

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RD-TDP43-Hu-48Tests	Reddot Biotech	48 Tests	EUR 600

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RD-TDP43-Hu-96Tests	Reddot Biotech	96 Tests	EUR 830.4

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
DLR-TDP43-Hu	DL Develop	96T	EUR 443
Description: serum, plasma, cerebrospinal fluid or other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
DL-TDP43-Hu	DL Develop	96T	EUR 421
Description: serum, plasma, cerebrospinal fluid or other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RDR-TDP43-Hu-48T	Reddot Biotech	48T	EUR 453.92
Description: serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RDR-TDP43-Hu-96T	Reddot Biotech	96T	EUR 648.38
Description: serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RD-TDP43-Hu-48T	Reddot Biotech	48T	EUR 432.3
Description: serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
RD-TDP43-Hu-96T	Reddot Biotech	96T	EUR 617.5
Description: serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKU07570-48T	Biomatik Corporation	48T	EUR 527.66

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKU07570-5x96T	Biomatik Corporation	5x96T	EUR 3580.55

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKU07570-96T	Biomatik Corporation	96T	EUR 753.8

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKN48681-48T	Biomatik Corporation	48T	EUR 359.87

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKN48681-5x96T	Biomatik Corporation	5x96T	EUR 2441.98

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKN48681-96T	Biomatik Corporation	96T	EUR 514.1

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKL60910-5x96T	Biomatik Corporation	5x96T	EUR 3622.83

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
EKL60910-96T	Biomatik Corporation	96T	EUR 762.7

Human TDP43(Tar DNA Binding Protein 43KDa) ELISA Kit
EH3862	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human Tar DNA Binding Protein 43kDa ELISA Kit (TDP43)
RK02369	Abclonal	96 Tests	EUR 625.2

Human TDP43(Tar DNA Binding Protein 43KDa) ELISA Kit
EKF57728-48T	Biomatik Corporation	48T	EUR 396.9

Human TDP43(Tar DNA Binding Protein 43KDa) ELISA Kit
EKF57728-5x96T	Biomatik Corporation	5x96T	EUR 2693.25

Human TDP43(Tar DNA Binding Protein 43KDa) ELISA Kit
EKF57728-96T	Biomatik Corporation	96T	EUR 567

Human TDP43(Tar DNA Binding Protein 43kDa) ELISA Kit
ELK2378-48T	ELK Biotech	48T	Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TDP43. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TDP43. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human TDP43, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human TDP43 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human TDP43(Tar DNA Binding Protein 43kDa) ELISA Kit
ELK2378-96T	ELK Biotech	96T	Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TDP43. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TDP43. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human TDP43, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human TDP43 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human TAR DNA binding protein 43,TARDBP/TDP-43 ELISA Kit
201-12-0334	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human TAR DNA binding protein 43(TARDBP/TDP-43)ELISA Kit
GA-E0350HM-48T	GenAsia Biotech	48T	EUR 346.8

Human TAR DNA binding protein 43(TARDBP/TDP-43)ELISA Kit
GA-E0350HM-96T	GenAsia Biotech	96T	EUR 559.2

Mouse TAR DNA binding protein 43(TARDBP/TDP-43) ELISA Kit
QY-E21735	Qayee Biotechnology	96T	EUR 448.8

Human TAR DNA binding protein 43(TARDBP/TDP-43)ELISA Kit
QY-E04553	Qayee Biotechnology	96T	EUR 433.2

Human TAR DNA binding protein 43,TARDBP/TDP-43 ELISA Kit
YLA0479HU-48T	Shanghai YL Biotech	48T	EUR 435

Human TAR DNA binding protein 43,TARDBP/TDP-43 ELISA Kit
YLA0479HU-96T	Shanghai YL Biotech	96T	EUR 562.5

ELISA kit for Human TDP43 (Tar DNA Binding Protein 43kDa)
ELK2378	ELK Biotech	1 plate of 96 wells	EUR 518.4
Description: A sandwich ELISA kit for detection of Tar DNA Binding Protein 43kDa from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
4-RPB951Hu01	Cloud-Clone	EUR 588.79 EUR 280.80 EUR 1877.95 EUR 705.98 EUR 1291.97 EUR 469.20 EUR 4514.88	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tar DNA Binding Protein 43kDa expressed in: E.coli

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
4-RPB951Mu01	Cloud-Clone	EUR 603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tar DNA Binding Protein 43kDa expressed in: E.coli

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
RPU43947-100ug	Biomatik Corporation	100ug	EUR 537.9

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
RPU43947-1mg	Biomatik Corporation	1mg	EUR 2380.3

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
RPU43947-50ug	Biomatik Corporation	50ug	EUR 431.2

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
RPU43948-100ug	Biomatik Corporation	100ug	EUR 554.4

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
RPU43948-1mg	Biomatik Corporation	1mg	EUR 2457

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
RPU43948-50ug	Biomatik Corporation	50ug	EUR 445.5

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody
CAU25007-100ul	Biomatik Corporation	100ul	EUR 229.4

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody
CAU25007-200ul	Biomatik Corporation	200ul	EUR 287.3

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody
CAU25008-100ul	Biomatik Corporation	100ul	EUR 222.7

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody
CAU25008-200ul	Biomatik Corporation	200ul	EUR 278.9

CLIA kit for Human TDP43 (Tar DNA Binding Protein 43KDa )
E-CL-H0642	Elabscience Biotech	1 plate of 96 wells	EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human TDP43 (Tar DNA Binding Protein 43KDa ) in samples from Serum, Plasma, Cell supernatant

Tar DNA Binding Protein 43kDa (TDP43) Magnetic Luminex Assay Kit
LKU601015-96T	Biomatik Corporation	96T	EUR 917.7

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human)
4-PAB951Hu01	Cloud-Clone	EUR 286.80 EUR 2869.20 EUR 717.60 EUR 358.80 EUR 253.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43)

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse)
4-PAB951Mu01	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43)

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human), PE
4-PAB951Hu01-PE	Cloud-Clone	EUR 344.40 EUR 3012.00 EUR 860.40 EUR 430.80 EUR 230.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with PE.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse), PE
4-PAB951Mu01-PE	Cloud-Clone	EUR 350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with PE.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human), APC
4-PAB951Hu01-APC	Cloud-Clone	EUR 399.60 EUR 3735.60 EUR 1046.40 EUR 507.60 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with APC.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human), Cy3
4-PAB951Hu01-Cy3	Cloud-Clone	EUR 483.60 EUR 4930.80 EUR 1345.20 EUR 627.60 EUR 294.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with Cy3.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human), HRP
4-PAB951Hu01-HRP	Cloud-Clone	EUR 366.00 EUR 3256.80 EUR 926.40 EUR 459.60 EUR 243.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with HRP.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse), APC
4-PAB951Mu01-APC	Cloud-Clone	EUR 408.00 EUR 3843.60 EUR 1072.80 EUR 518.40 EUR 260.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with APC.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse), Cy3
4-PAB951Mu01-Cy3	Cloud-Clone	EUR 493.20 EUR 5074.80 EUR 1381.20 EUR 642.00 EUR 297.60	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with Cy3.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse), HRP
4-PAB951Mu01-HRP	Cloud-Clone	EUR 373.20 EUR 3350.40 EUR 949.20 EUR 469.20 EUR 246.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with HRP.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human), FITC
4-PAB951Hu01-FITC	Cloud-Clone	EUR 344.40 EUR 3012.00 EUR 860.40 EUR 430.80 EUR 230.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with FITC.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse), FITC
4-PAB951Mu01-FITC	Cloud-Clone	EUR 350.40 EUR 3098.40 EUR 882.00 EUR 439.20 EUR 232.80	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with FITC.

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit
CSB-E17007h-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from serum, plasma, cell culture supernates, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit
1-CSB-E17007h	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from serum, plasma, cell culture supernates, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA Kit
KTE60478-96T5	Abbkine	96 T×5	EUR 2629
Description: This Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA Kit employs a two-site sandwich ELISA to quantitate TARDBP.

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA Kit
KTE60478-96T50	Abbkine	96 T×50	EUR 24569
Description: This Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA Kit employs a two-site sandwich ELISA to quantitate TARDBP.

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit
EKC41252-48T	Biomatik Corporation	48T	EUR 535.99

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit
EKC41252-5x96T	Biomatik Corporation	5x96T	EUR 3637.08

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit
EKC41252-96T	Biomatik Corporation	96T	EUR 765.7

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human), Biotinylated
4-PAB951Hu01-Biotin	Cloud-Clone	EUR 363.60 EUR 2809.20 EUR 836.40 EUR 442.80 EUR 259.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with Biotin.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse), Biotinylated
4-PAB951Mu01-Biotin	Cloud-Clone	EUR 368.40 EUR 2888.40 EUR 856.80 EUR 450.00 EUR 260.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with Biotin.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human), APC-Cy7
4-PAB951Hu01-APC-Cy7	Cloud-Clone	EUR 656.40 EUR 7327.20 EUR 1948.80 EUR 872.40 EUR 372.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with APC-Cy7.

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse), APC-Cy7
4-PAB951Mu01-APC-Cy7	Cloud-Clone	EUR 672.00 EUR 7543.20 EUR 2002.80 EUR 894.00 EUR 378.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43). This antibody is labeled with APC-Cy7.

ELISA kit for Human TAR DNA-binding protein 43 (TARDBP/TDP43)
KTE60478-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human TAR DNA-binding protein 43 (TARDBP/TDP43)
KTE60478-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human TAR DNA-binding protein 43 (TARDBP/TDP43)
KTE60478-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Rat TAR DNA Binding Protein 43 ELISA kit
E02T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat TAR DNA Binding Protein 43 ELISA kit
E02T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat TAR DNA Binding Protein 43 ELISA kit
E02T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx256037-96tests	Abbexa	96 tests	EUR 904.8

Dog TAR DNA Binding Protein 43 ELISA kit
E08T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog TAR DNA Binding Protein 43 ELISA kit
E08T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog TAR DNA Binding Protein 43 ELISA kit
E08T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA Binding Protein 43 ELISA kit
E07T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA Binding Protein 43 ELISA kit
E07T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA Binding Protein 43 ELISA kit
E07T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA Binding Protein 43 ELISA kit
E06T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA Binding Protein 43 ELISA kit
E06T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA Binding Protein 43 ELISA kit
E06T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA Binding Protein 43 ELISA kit
E03T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA Binding Protein 43 ELISA kit
E03T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA Binding Protein 43 ELISA kit
E03T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA Binding Protein 43 ELISA kit
E01T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA Binding Protein 43 ELISA kit
E01T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA Binding Protein 43 ELISA kit
E01T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA Binding Protein 43 ELISA kit
E04T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA Binding Protein 43 ELISA kit
E04T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA Binding Protein 43 ELISA kit
E04T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA Binding Protein 43 ELISA kit
E09T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA Binding Protein 43 ELISA kit
E09T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA Binding Protein 43 ELISA kit
E09T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238573-100ug	Abbexa	100 ug	EUR 577.2

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238574-100ug	Abbexa	100 ug	EUR 610.8

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238575-100ug	Abbexa	100 ug	EUR 610.8

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238576-100ug	Abbexa	100 ug	EUR 661.2

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238577-100ug	Abbexa	100 ug	EUR 661.2

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx431750-200ul	Abbexa	200 ul	EUR 460.8

Pig TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx361185-96tests	Abbexa	96 tests	EUR 990

Guinea pig TAR DNA Binding Protein 43 ELISA kit
E05T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig TAR DNA Binding Protein 43 ELISA kit
E05T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig TAR DNA Binding Protein 43 ELISA kit
E05T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx253259-96tests	Abbexa	96 tests	EUR 848.4

Mouse TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx254453-96tests	Abbexa	96 tests	EUR 904.8

W tym przeglądzie omówimy, w jaki sposób siła i charakter zdarzeń sygnalizacyjnych TCR wpływają na rozwój samoreaktywnych limfocytów T i napędzają progresję T1D poprzez wpływ na ekspresję genów limfocytów T, zaangażowanie w linię i utrzymanie patogennej anty-własnej T funkcja efektorowa komórki.