Aktualne trendy w strategiach terapeutycznych w leczeniu cukrzycy

Cukrzyca jest jedną z najszybciej rozwijających się chorób niezakaźnych. Cukrzyca jest spowodowana zniszczeniem komórek beta trzustki lub z insulinoopornością i charakteryzuje się hiperglikemią. Cukrzyca powoduje bardzo poważny kryzys gospodarczy, ponieważ rynek leków na cukrzycę rozwija się bardzo szybko. Nawet po przełomowych odkryciach naukowych, dostępności lepszej infrastruktury opieki zdrowotnej, wzroście poziomu umiejętności czytania i pisania, ciężar cukrzycy stale rozprzestrzenia się w różnych sekcjach na całym świecie, a zwłaszcza w krajach o niskich i średnich dochodach.

Niedawny rozwój odkryć naukowych zaowocował powstaniem szeregu nowych generacji leków przeciwcukrzycowych, takich jak sulfonylomocznik, biguanidy, tiazolidynodion, inhibitory alfa glukozydazy. Wszystkie te leki wykazały znaczące obniżenie poziomu glukozy we krwi. Opracowano również i opisano kilka nowych klas leków hipoglikemizujących, takich jak analogi GLP-1, inhibitory DPP-IV, inhibitory amyliny, receptory aktywowane przez proliferatory peroksysomów.

Istnieją pewne aktywne cząsteczki i substancje bioaktywne zostały oczyszczone z ziół i roślin, co dodaje wartości do wojny z cukrzycą. Te fitokomponenty zniweczyły rozwój leków i doprowadziły do ​​identyfikacji leków na cukrzycę. Przegląd koncentruje się również na niektórych krytycznych obszarach cukrzycy, ze szczególnym uwzględnieniem podejścia do leczenia cukrzycy opartego na statynach oraz terapii przeciwcukrzycowej nowej generacji opartej na komórkach macierzystych.

Otyłość, cukrzyca typu 2 i ryzyko raka

Otyłość i cukrzyca typu 2 są związane ze zwiększonym ryzykiem raka i stają się coraz częstsze. Nieprawidłowości metaboliczne, takie jak insulinooporność i dyslipidemia, są związane zarówno z otyłością, jak i cukrzycą typu 2 i mają wpływ na związek otyłość-rak. Zaproponowano wiele mechanizmów łączących otyłość i cukrzycę z progresją raka, w tym wzrost sygnalizacji insuliny / IGF-1, wychwytu i metabolizmu lipidów i glukozy, zmiany w profilu cytokin, chemokin i adipokin, a także zmiany w tkanka tłuszczowa bezpośrednio sąsiadująca z miejscami raka. Niniejszy przegląd ma na celu podsumowanie i przedstawienie aktualnych danych epidemiologicznych i mechanistycznych łączących otyłość i cukrzycę typu 2 z rakiem, ze szczególnym uwzględnieniem roli insuliny, lipidów i tkanki tłuszczowej.

Słodki i słony: cukrzycowa kwasica ketonowa u pacjenta z nefrogenną cukrzycą prostą

Współwystępowanie nefrogennej moczówki prostej (NDI) z cukrzycą (DM) u pacjenta z cukrzycową kwasicą ketonową (DKA) jest rzadkie i, według naszej wiedzy, nie zostało opisane nawet w opisach przypadków. Przedstawiamy przypadek 16-letniego mężczyzny ze znanym NDI, który zgłosił się na jeden dzień na oddział ratunkowy (SOR) u dzieci z uogólnionym osłabieniem i zmniejszonym apetytem, ​​u którego stwierdzono umiarkowaną CKK po pojawieniu się DM.

Początkowe leczenie odwodnienia i stanu hiperosmolarnego stanowiło wyjątkowe wyzwanie. Resuscytacja płynami izotonicznymi płynami u pacjenta z NDI stwarza ryzyko nasilenia hipernatremii, co może prowadzić do drgawek i śmierci. Jednak stosowanie płynów hipotonicznych może zbyt szybko obniżyć osmolalność surowicy, co może skutkować obrzękiem mózgu.

Konsultanci nefrologii, endokrynologii i pediatrycznego oddziału intensywnej opieki medycznej (PICU) zostali powiadomieni o tym pacjencie i skoordynowano dyskusję między pod-specjalistami w celu ustalenia odpowiedniej resuscytacji płynowej. Pacjentowi pozwolono pić bezpłatną wodę oprócz dożylnych płynów (IVF) 5% dekstrozy z 0,2% chlorkiem sodu z szybkością półtorej dawki podtrzymującej (150 ml / godz.) Na SOR przed transferem na OIT, gdzie rozpoczęto wlew insuliny. Ten opis przypadku zawiera wytyczne dla personelu szpitalnego dotyczące postępowania z pacjentami ze współistniejącymi NDI i DM w DKA, rzadkim połączeniu, które wymaga przemyślanego i pilnego leczenia.

Sygnatura mikroRNA osocza związana z retinopatią u pacjentów z cukrzycą typu 2

Retinopatia cukrzycowa (DR) jest główną przyczyną utraty wzroku i niepełnosprawności. Skuteczne leczenie DR zależy od szybkiego leczenia i przyniosłoby korzyści z biomarkerów do badań przesiewowych i przedobjawowego wykrywania retinopatii u pacjentów z cukrzycą. MikroRNA (miRNA) to post-transkrypcyjne regulatory ekspresji genów, które są uwalniane we krwi i mogą służyć jako biomarkery. Niewiele wiadomo na temat krążących miRNA u pacjentów z cukrzycą typu 2 (T2DM) i DR.

Tutaj pokazujemy, że DR jest związane z wyższym krążącym miR-25-3p (P = 0,004) i miR-320b (P = 0,011) oraz niższymi poziomami miR-495-3p (P <0,001) w kohorcie pacjentów z T2DM z DR (n = 20), w porównaniu z osobami z cukrzycą bez DR (n = 10) i osobami zdrowymi (n = 10). Zależności te utrzymywały się znaczące po dostosowaniu do wieku, płci i HbA1c. Poziomy krążących miRNA korelowały z ciężkością choroby, a ich towarzysząca ocena wykazała wysoką dokładność identyfikacji DR (AUROC = 0,93; P <0,001).

Analiza ontologii genów zweryfikowanych celów wykazała wzbogacenie szlaków, takich jak regulacja procesów metabolicznych (P = 1,5 × 10-20), odpowiedź komórek na stres (P = 1,9 × 10-14) i rozwój naczyń krwionośnych (P = 2,7 × 10-14). W oczekiwaniu na zewnętrzną walidację spodziewamy się, że te miRNA mogą służyć jako domniemane biomarkery choroby i uwydatniać nowe cele molekularne w celu poprawy opieki nad pacjentami z retinopatią cukrzycową.

Rola sygnalizacji receptora komórek T w rozwoju cukrzycy typu 1

Sygnalizacja receptora komórek T (TCR) wpływa na wiele aspektów immunobiologii limfocytów T CD4 + i CD8 +, w tym rozwój grasicy, homeostazę obwodową, różnicowanie / funkcję podzbiorów efektorowych i tworzenie pamięci. Dodatkowe wskazówki sygnalizacyjne komórek T wyzwalane przez cząsteczki kostymulujące i cytokiny również wpływają na czas trwania sygnalizacji TCR, a także dodatkowe szlaki, które dodatkowo kształtują odpowiedź komórek T.

Cukrzyca typu 1 (T1D) jest chorobą autoimmunologiczną kierowaną przez komórki T, której celem są komórki β trzustki wytwarzające insulinę. Dowody wskazują, że rozregulowane zdarzenia sygnalizacyjne TCR w T1D wpływają na skuteczność ośrodkowych i obwodowych mechanizmów wywołujących tolerancję.

ELISA kit for Rat TDP43 (TAR DNA Binding Protein 43)
E-EL-R2479	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat TDP43 (TAR DNA Binding Protein 43) in samples from Serum, Plasma, Cell supernatant

TDP43 ELISA Kit| Rat TAR DNA Binding Protein 43 ELISA Kit
EF018066	Lifescience Market	96 Tests	EUR 826.8

Tar DNA Binding Protein 43 kDa (TDP43) Antibody
20-abx103209	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Tar DNA Binding Protein 43 kDa (TDP43) Antibody
20-abx103210	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Tar DNA Binding Protein 43 kDa (TDP43) Antibody
20-abx174716	Abbexa	EUR 978.00 EUR 510.00	1 mg 200 ug

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit
CSB-E17007h-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from serum, plasma, cell culture supernates, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human TAR DNA-binding protein 43 (TARDBP/TDP43) ELISA kit
1-CSB-E17007h	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from serum, plasma, cell culture supernates, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

ELISA kit for Human TDP43 (TAR DNA Binding Protein 43)
E-EL-H0942	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human TDP43 (TAR DNA Binding Protein 43) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse TDP43 (TAR DNA Binding Protein 43)
E-EL-M1115	Elabscience Biotech	1 plate of 96 wells	EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse TDP43 (TAR DNA Binding Protein 43) in samples from Serum, Plasma, Cell supernatant

TDP43 ELISA Kit| Mouse TAR DNA Binding Protein 43 ELISA Kit
EF013922	Lifescience Market	96 Tests	EUR 826.8

Human Tar DNA Binding Protein 43 kDa (TDP43) Protein
20-abx069231	Abbexa	EUR 828.00 EUR 343.20 EUR 2532.00 EUR 978.00 EUR 594.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Tar DNA Binding Protein 43 kDa (TDP43) Protein
20-abx069232	Abbexa	EUR 844.80 EUR 343.20 EUR 2598.00 EUR 994.80 EUR 594.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Tar DNA Binding Protein 43 kDa (TDP43) CLIA Kit
abx197753-96tests	Abbexa	96 tests	EUR 990

ELISA kit for Human TAR DNA-binding protein 43 (TARDBP/TDP43)
KTE60478-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human TAR DNA-binding protein 43 (TARDBP/TDP43)
KTE60478-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human TAR DNA-binding protein 43 (TARDBP/TDP43)
KTE60478-96T	Abbkine	96T	EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human TAR DNA-binding protein 43 (TARDBP/TDP43) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Rat TAR DNA Binding Protein 43 ELISA kit
E02T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat TAR DNA Binding Protein 43 ELISA kit
E02T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat TAR DNA Binding Protein 43 ELISA kit
E02T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
4-RPB951Hu01	Cloud-Clone	EUR 588.79 EUR 280.80 EUR 1877.95 EUR 705.98 EUR 1291.97 EUR 469.20 EUR 4514.88	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Tar DNA Binding Protein 43kDa expressed in: E.coli

Recombinant Tar DNA Binding Protein 43kDa (TDP43)
4-RPB951Mu01	Cloud-Clone	EUR 603.84 EUR 285.60 EUR 1934.40 EUR 724.80 EUR 1329.60 EUR 480.00 EUR 4656.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Tar DNA Binding Protein 43kDa expressed in: E.coli

Human TDP43(Tar DNA Binding Protein 43KDa) ELISA Kit
EH3862	FN Test	96T	EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
SEB951Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in serum, plasma, cerebrospinal fluid and other biological fluids.

Human Tar DNA Binding Protein 43kDa (TDP43) ELISA Kit
4-SEB951Hu	Cloud-Clone	EUR 5463.60 EUR 2886.00 EUR 735.60	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tar DNA Binding Protein 43kDa (TDP43) in samples from serum, plasma, cerebrospinal fluid and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Tar DNA Binding Protein 43kDa ELISA Kit (TDP43)
RK02369	Abclonal	96 Tests	EUR 625.2

TAR DNA-binding protein 43 Antibody
20-abx137436	Abbexa	EUR 844.80 EUR 393.60 EUR 276.00	100 ug 20 ug 5 ug

Rat TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx256037-96tests	Abbexa	96 tests	EUR 904.8

Rat TAR DNA-binding protein 43(TARDBP) ELISA kit
E02T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat TAR DNA-binding protein 43(TARDBP) ELISA kit
E02T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat TAR DNA-binding protein 43(TARDBP) ELISA kit
E02T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rat TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA Binding Protein 43 ELISA kit
E06T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA Binding Protein 43 ELISA kit
E06T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA Binding Protein 43 ELISA kit
E06T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA Binding Protein 43 ELISA kit
E04T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA Binding Protein 43 ELISA kit
E04T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA Binding Protein 43 ELISA kit
E04T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA Binding Protein 43 ELISA kit
E03T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA Binding Protein 43 ELISA kit
E03T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA Binding Protein 43 ELISA kit
E03T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog TAR DNA Binding Protein 43 ELISA kit
E08T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog TAR DNA Binding Protein 43 ELISA kit
E08T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog TAR DNA Binding Protein 43 ELISA kit
E08T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA Binding Protein 43 ELISA kit
E09T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA Binding Protein 43 ELISA kit
E09T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA Binding Protein 43 ELISA kit
E09T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA Binding Protein 43 ELISA kit
E01T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA Binding Protein 43 ELISA kit
E01T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA Binding Protein 43 ELISA kit
E01T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA Binding Protein 43 ELISA kit
E07T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA Binding Protein 43 ELISA kit
E07T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA Binding Protein 43 ELISA kit
E07T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx431750-200ul	Abbexa	200 ul	EUR 460.8

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238573-100ug	Abbexa	100 ug	EUR 577.2

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238574-100ug	Abbexa	100 ug	EUR 610.8

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238575-100ug	Abbexa	100 ug	EUR 610.8

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238576-100ug	Abbexa	100 ug	EUR 661.2

TAR DNA-Binding Protein 43 (TDP-43) Antibody
abx238577-100ug	Abbexa	100 ug	EUR 661.2

ELISA kit for Human TDP43 (Tar DNA Binding Protein 43kDa)
ELK2378	ELK Biotech	1 plate of 96 wells	EUR 518.4
Description: A sandwich ELISA kit for detection of Tar DNA Binding Protein 43kDa from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human TAR DNA binding protein 43,TARDBP/TDP-43 ELISA Kit
201-12-0334	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human TAR DNA binding protein 43(TARDBP/TDP-43)ELISA Kit
GA-E0350HM-48T	GenAsia Biotech	48T	EUR 346.8

Human TAR DNA binding protein 43(TARDBP/TDP-43)ELISA Kit
GA-E0350HM-96T	GenAsia Biotech	96T	EUR 559.2

Human TAR DNA binding protein 43(TARDBP/TDP-43)ELISA Kit
QY-E04553	Qayee Biotechnology	96T	EUR 433.2

Mouse TAR DNA binding protein 43(TARDBP/TDP-43) ELISA Kit
QY-E21735	Qayee Biotechnology	96T	EUR 448.8

TAR DNA-Binding Protein 43 (TARDBP) Antibody
20-abx142258	Abbexa	EUR 444.00 EUR 727.20 EUR 376.80	100 ul 200 ul 50 ul

TAR DNA-Binding Protein 43 (TARDBP) Antibody
20-abx001097	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

TAR DNA-Binding Protein 43 (TARDBP) Antibody
20-abx127061	Abbexa	EUR 493.20 EUR 710.40	100 ul 200 ul

TAR DNA-Binding Protein 43 (TARDBP) Antibody
abx027591-400ul	Abbexa	400 ul	EUR 627.6

TAR DNA-Binding Protein 43 (TARDBP) Antibody
abx027591-80l	Abbexa	80 µl	EUR 343.2

TAR DNA-Binding Protein 43 (TARDBP) Antibody
20-abx322339	Abbexa	EUR 360.00 EUR 292.80	100 ul 50 ul

TAR DNA-Binding Protein 43 (TARDBP) Antibody
abx218873-100ug	Abbexa	100 ug	EUR 526.8

TAR DNA-Binding Protein 43 (TARDBP) Antibody
abx224178-100ug	Abbexa	100 ug	EUR 493.2

TAR DNA-Binding Protein 43 (TARDBP) Antibody
20-abx302614	Abbexa	EUR 794.40 EUR 334.80 EUR 526.80	100 ug 20 ug 50 ug

Human TAR DNA-binding protein 43 (TARDBP)
1-CSB-EP023129HU	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human TAR DNA-binding protein 43(TARDBP),partial expressed in E.coli

Human TAR DNA-binding protein 43 (TARDBP)
1-CSB-EP023129HUe0	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human TAR DNA-binding protein 43(TARDBP),partial expressed in E.coli

Human TAR DNA-binding protein 43 (TARDBP)
1-CSB-YP023129HU	Cusabio	EUR 516.00 EUR 280.80 EUR 1809.60 EUR 770.40 EUR 1210.80 EUR 349.20	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human TAR DNA-binding protein 43(TARDBP),partial expressed in Yeast

Human TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
20-abx153245	Abbexa	EUR 8534.40 EUR 4550.40 EUR 1054.80	10 × 96 tests 5 × 96 tests 96 tests

Chicken TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx356727-96tests	Abbexa	96 tests	EUR 990

Monkey TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx359355-96tests	Abbexa	96 tests	EUR 990

Rabbit TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx363228-96tests	Abbexa	96 tests	EUR 990

Sheep TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx364152-96tests	Abbexa	96 tests	EUR 1111.2

Pig TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx361185-96tests	Abbexa	96 tests	EUR 990

Human TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx253259-96tests	Abbexa	96 tests	EUR 848.4

Mouse TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx254453-96tests	Abbexa	96 tests	EUR 904.8

Chicken TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx518925-96tests	Abbexa	96 tests	EUR 990

Mouse TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx518927-96tests	Abbexa	96 tests	EUR 904.8

Human TAR DNA Binding Protein 43 (TARDBP) ELISA Kit
abx572190-96tests	Abbexa	96 tests	EUR 848.4

Goat TAR DNA-binding protein 43(TARDBP) ELISA kit
E06T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA-binding protein 43(TARDBP) ELISA kit
E06T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat TAR DNA-binding protein 43(TARDBP) ELISA kit
E06T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Goat TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA-binding protein 43(TARDBP) ELISA kit
E04T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA-binding protein 43(TARDBP) ELISA kit
E04T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit TAR DNA-binding protein 43(TARDBP) ELISA kit
E04T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA-binding protein 43(TARDBP) ELISA kit
E03T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA-binding protein 43(TARDBP) ELISA kit
E03T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA-binding protein 43(TARDBP) ELISA kit
E03T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig TAR DNA Binding Protein 43 ELISA kit
E05T0108-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig TAR DNA Binding Protein 43 ELISA kit
E05T0108-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig TAR DNA Binding Protein 43 ELISA kit
E05T0108-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA Binding Protein 43 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA-binding protein 43(TARDBP) ELISA kit
E09T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA-binding protein 43(TARDBP) ELISA kit
E09T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey TAR DNA-binding protein 43(TARDBP) ELISA kit
E09T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TARDBP/ TAR DNA-binding protein 43 ELISA Kit
E2446Hu	Sunlong	1 Kit	EUR 685.2

Dog TAR DNA-binding protein 43(TARDBP) ELISA kit
E08T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog TAR DNA-binding protein 43(TARDBP) ELISA kit
E08T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog TAR DNA-binding protein 43(TARDBP) ELISA kit
E08T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Canine TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human TAR DNA-binding protein 43
EK4117	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human TAR DNA-binding protein 43 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human TAR DNA-binding protein 43(TARDBP) ELISA kit
E01T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA-binding protein 43(TARDBP) ELISA kit
E01T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human TAR DNA-binding protein 43(TARDBP) ELISA kit
E01T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA-binding protein 43(TARDBP) ELISA kit
E07T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA-binding protein 43(TARDBP) ELISA kit
E07T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig TAR DNA-binding protein 43(TARDBP) ELISA kit
E07T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse TAR DNA- binding protein 43, Tardbp ELISA KIT
ELI-06265m	Lifescience Market	96 Tests	EUR 1038

Human TAR DNA- binding protein 43, TARDBP ELISA KIT
ELI-06266h	Lifescience Market	96 Tests	EUR 988.8

Chicken TAR DNA- binding protein 43, TARDBP ELISA KIT
ELI-06267c	Lifescience Market	96 Tests	EUR 1113.6

CLIA kit for Human TDP43 (Tar DNA Binding Protein 43KDa )
E-CL-H0642	Elabscience Biotech	1 plate of 96 wells	EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human TDP43 (Tar DNA Binding Protein 43KDa ) in samples from Serum, Plasma, Cell supernatant

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Human)
4-PAB951Hu01	Cloud-Clone	EUR 286.80 EUR 2869.20 EUR 717.60 EUR 358.80 EUR 253.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Tar DNA Binding Protein 43kDa (TDP43)

Tar DNA Binding Protein 43kDa (TDP43) Polyclonal Antibody (Mouse)
4-PAB951Mu01	Cloud-Clone	EUR 291.60 EUR 2948.40 EUR 735.60 EUR 366.00 EUR 254.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Tar DNA Binding Protein 43kDa (TDP43)

Guinea pig TAR DNA-binding protein 43(TARDBP) ELISA kit
E05T0660-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig TAR DNA-binding protein 43(TARDBP) ELISA kit
E05T0660-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig TAR DNA-binding protein 43(TARDBP) ELISA kit
E05T0660-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig TAR DNA-binding protein 43(TARDBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Mouse TAR DNA-binding protein 43 (TARDBP)
KTE70347-48T	Abbkine	48T	EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse TAR DNA-binding protein 43 (TARDBP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse TAR DNA-binding protein 43 (TARDBP)
KTE70347-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse TAR DNA-binding protein 43 (TARDBP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

W tym przeglądzie omówimy, w jaki sposób siła i charakter zdarzeń sygnalizacyjnych TCR wpływają na rozwój samoreaktywnych limfocytów T i napędzają progresję T1D poprzez wpływ na ekspresję genów limfocytów T, zaangażowanie w linię i utrzymanie patogennej anty-własnej T funkcja efektorowa komórki.